gastric ulcer

The present work was designed to investigate the anti-ulcer activities of methanolic extract of artocarpusaltilis [breadfruit] on alcohol induce ulcer in male albino rats. Animals were administered orally with a single dose of 98‰ alcohol [depending on the animals’ weight] to induce ulcer. This resulted in significant increase in ulcer occurrence [exacerbation]. Both the induced and normal rats were divided into six groups of 5 rats each. Group 1 was the control group [induced but not treated] while group 2 received 100mg/kg dose of aqueous extract of artocarpusaltilis. Group 3 and 4 received 200mg/kg and 300mg/kg dose of aqueous extract of artocarpusaltilis respectively. Group 5 received 10mg/kg per oral dose of omeprazole [standard drug]. Administration of methanolic extract of artocarpusaltilis produce a decrease in ulcer occurrence in induced rats. The decrease in ulcer occurrence was significant [p‹0.005] with all the groups treated with methanolic extract of artocarpusaltilis when compared to the control group. But group 3 and 4 exclusively showed same potency when compared to group 5 [standard drug]. The decrease in ulcer incidence when compared to the control group [ulcer induced but not treated] and for exhibiting same potency with the standard drug shows that the extract of artocarpusaltilis  is effective in controlling ulcer and can be used as a substitute for the standard drug in managing or treating/controlling ulcer. Conclusively, methanolic extract of artocarpusaltilis has tremendous beneficial anti-ulcer values in the treatment of ulcer following oral administration.

The study was designed to investigate the gastro protective effects of fruit extracts of Artocarpus altilis (Breadfruit), using alcohol induced acute ulcer model. The extracts were administered at doses100mg/kg, 200mg/kg and 300mg/kg. 10mg/kg of Omeprazole was used as a reference standard. The parameters used for this were percentage of animals with gastric ulcer (UP), ulcer index (UI) and percentage protection of ulcer (%P). The percentage of animals with ulcer was lowest in both the groups treated with 300mg/kg (16.67 ± 0.004) of extract and those treated with omeprazole (16.67 ± 0.004). While the animals in control group and those treated with 100mg/kg of extract had the highest percentage of animals with ulcer (100.01 ± 0.005). The gastro protective activity was accessed by determining and comparing the ulcer index in the test group with that of the control group. Animals pretreated with Artocarpus altilis extract showed significant reduction in ulcer index in a dose dependent manner when compared to the control group having an ulcer index of 11.51 ± 0.005 when treated 100mg/kg of extract, 3.66 ± 0.004 & 1.83± 0.004 for 200mg/kg & 300mg/kg of extract respectively. The gastro protective effect of 300mg/kg had the same potency as the standard drug Omeprazole. The administration of 100mg/kg, 200mg/kg, 300mg/kg and Standard drug (Omeprazole) reduced Gastric lesions by 9%, 71%, 85.5% and 85.5% respectively. The results suggest that the extract possesses significant protective properties against ulcer in albino rat compared to the control group.

 Aloe vera are widely used in the cosmetics and alternative medicine industries, being marketed as variously having rejuvenating, healing, or soothing properties. There is, however, little scientific evidence of the effectiveness or safety of Aloe vera extracts for either cosmetic or medicinal purposes, and what positive evidence is available is frequently contradicted by other studies. Aloe vera has been used as a popular folk medicine. It is a colourless mucilaginous gel obtained from the parenchymatous cells in the fresh leaves of Aloe vera. It has been claimed that Aloe vera gel has the ability to cure gastric ulcers or protect against its formation in both animals and humans. This study evaluates the effect of Aloe vera gel on gastric and duodenal ulcers and determines its interaction with conventionally used antiulcer drugs; pantoprazole. The antiulcer activity of Aloe vera gel at three different doses and its interaction with Pantoprazole was evaluated in, pylorus ligation induced gastric ulcer, stress induced gastric ulcer and  indomethacin induced gastric ulcer  models. In all these models, the common parameter determined was ulcer index. All the three doses of Aloe vera gel produced marginal ulcer healing effect and augmented the ulcer healing effect of pantoprazole in stress and Indomethacin induced gastric ulcers, while in pylorus ligated rats, Aloe vera gel demonstrated gastric anti-secretory and antiulcer effect. Aloe vera gel possesses dose dependent antiulcer effect and augments the antiulcer action pantoprazole in rats.

  The current study was undertaken to investigate the effect of the avipattikar churna against experimental gastric ulcers. Pretreatment of aqueous extract of churna at the dose of 540 mg/kg, for seven days was studied against ethanol-induced gastric mucosal damage. The aqueous extract showed significant reduction in gastric ulceration against ethanol-induced gastric mucosal damage. The results were comparable with omeprazole (reference standard). In the ethanol-induced gastric ulcer model, treatment with both the aqueous extract and omeprazole showed significant antioxidant activity as evident from the reduction in the extent of lipid peroxidation that was measured in terms of malondialdehyde (MDA), when compared with the control group. Pretreatment of aqueous extract of churna for 7 days in 6-h pylorus-ligated animals, showed significant reduction in the ulcer index. Furthermore, in the pylorus  ligation model, significant reduction (p