AR Shabaraya

The purpose of the study was to prepare and evaluate liposomes containing Artemether, a lipophilic drug having short half life of 2-3hrs after oral administration. Thin film hydration method was used for the preparation of artemether-encapsulated conventional and PEGylated liposomal suspensions using various drug: lipid ratio and their characteristics, such as particle size, zeta potential, encapsulation efficiency, and in vitro drug release were investigated. The drug encapsulation efficiency of PEGylated liposomes was high when compared to conventional liposomes. The average particle size of both conventional and PEGylated liposomes was obtained in nanometers with PDI ranging from 0-0.356. Zeta potential of conventional liposomes was found to be more negative when compared to PEGylated liposomes. In-vitro drug diffusion studies was carried for period of 16 hrs where PEGylated liposomal formulation showed more sustained release compared to conventional liposomes. The conventional and PEGylated liposomal formulations followed zero order and Higuchi kinetics respectively. The artemether containing liposomes were successfully formulated and evaluated.

Herbal medicine has become an integral part of standard healthcare based on combination of traditional usage and on-going scientific research. Gel is a semisolid system consisting of dispersion made up of either small inorganic particles or large organic molecules enclosing an interpenetrated liquid. The inorganic particles form a three dimensional structure. The gel formulation was designed by using ethanolic extract of Cassia tora seeds and evaluated for various physiological measurements; preparation involved various concentration combinations of Carbopol 934 and Sodium CMC. Containing 1.55%of Cassia tora extract, Glycerin, Methyl paraben, Propyl paraben and required amount of distilled water and neutralized by drop wise addition of tri-ethanolamine to get gel like consistency. The results of physiochemical parameters of formulations were pH (6.8 to 6.89), viscosity, spreadability, extrudability, in-vitro release respectively. Concentration and combination effect of Carbopol 934 and Sodium CMC showed increased consistency and sustained action with increase in concentration.