Anti-Ulcer Activities of Methanolic Extract of Artocarpusaltilis (Breadfruit) on Alcohol Induced Acute Ulcer Model in Albino Wistar Rats

The present work was designed to investigate the anti-ulcer activities of methanolic extract of artocarpusaltilis [breadfruit] on alcohol induce ulcer in male albino rats. Animals were administered orally with a single dose of 98‰ alcohol [depending on the animals’ weight] to induce ulcer. This resulted in significant increase in ulcer occurrence [exacerbation]. Both the induced and normal rats were divided into six groups of 5 rats each. Group 1 was the control group [induced but not treated] while group 2 received 100mg/kg dose of aqueous extract of artocarpusaltilis. Group 3 and 4 received 200mg/kg and 300mg/kg dose of aqueous extract of artocarpusaltilis respectively. Group 5 received 10mg/kg per oral dose of omeprazole [standard drug]. Administration of methanolic extract of artocarpusaltilis produce a decrease in ulcer occurrence in induced rats. The decrease in ulcer occurrence was significant [p‹0.005] with all the groups treated with methanolic extract of artocarpusaltilis when compared to the control group. But group 3 and 4 exclusively showed same potency when compared to group 5 [standard drug]. The decrease in ulcer incidence when compared to the control group [ulcer induced but not treated] and for exhibiting same potency with the standard drug shows that the extract of artocarpusaltilis  is effective in controlling ulcer and can be used as a substitute for the standard drug in managing or treating/controlling ulcer. Conclusively, methanolic extract of artocarpusaltilis has tremendous beneficial anti-ulcer values in the treatment of ulcer following oral administration.