A Facile Synthesis and the Study of Some New Chalcones for Analgesic and Anti-Inflammatory Activity

Some chalcones (2a-2n) were synthesized by the condensation of various substituted benzaldehydes and unsubstituted/4-bromo acetophenone by using Claisen-Schmidt condensation. This is a comparative study of synthesizing compounds by conventional as well as non-conventional microwave irradiation in a commercially modified microwave oven. The research is focused on the remarkable reaction rate enhancement by the use of various non-conventional microwave irradiations which minimizes the time and solvents in reactions. Variety of functional groups such as nitro, chloro, dimethylamino, methoxy and methyl survived under the reaction conditions. The structures of newly synthesized compounds have been established on the basis of IR, 1H NMR spectral data and elemental analysis. The synthesized compounds were screened for analgesic and anti-inflammatory activity.