Formulation and Evaluation of Levofloxacin Dental Strips for Periodontitis Diseases

Periodontitis is an inflammatory response to the overgrowth of anaerobic pathogenic organisms such as spirochetes and bactericides in the sub gingival plaque. If it is unchecked, results in the destruction of the bone and soft tissues supporting to the tooth, which leads to tooth loss. For treatment of these diseases we are preparing local drug delivery system of Levofloxacin dental strips. This helps to get local as well as sustained action against organism. Here we are used HPMC and ethyl cellulose as rate controlling polymer and dibutyl phthalate as plasticizers. Which shows tensile strength varies from 1.55-1.87 kg/cm2,the thickness varies from 0.33±0.002mm to 0.38±0.008mm. The weight variation and drug content was found to be uniform in all the formulation and folding endurance was found to be more than 200 in all the strips. In vitro dissolution was carried out by using static dissolution method and in vitro anti- bacterial activity was carried out by E.coli and S.aureus the zone of inhibition was calculated. The stability study was carried out under accelerated condition to found out the stability of all the formulation.