Srinivas Hebbar

Periodontitis is an inflammatory response to the overgrowth of anaerobic pathogenic organisms such as spirochetes and bactericides in the sub gingival plaque. If it is unchecked, results in the destruction of the bone and soft tissues supporting to the tooth, which leads to tooth loss. For treatment of these diseases we are preparing local drug delivery system of Levofloxacin dental strips. This helps to get local as well as sustained action against organism. Here we are used HPMC and ethyl cellulose as rate controlling polymer and dibutyl phthalate as plasticizers. Which shows tensile strength varies from 1.55-1.87 kg/cm2,the thickness varies from 0.33±0.002mm to 0.38±0.008mm. The weight variation and drug content was found to be uniform in all the formulation and folding endurance was found to be more than 200 in all the strips. In vitro dissolution was carried out by using static dissolution method and in vitro anti- bacterial activity was carried out by E.coli and S.aureus the zone of inhibition was calculated. The stability study was carried out under accelerated condition to found out the stability of all the formulation.

Medicated chewing gum (MCG) is a drug delivery system that consists of an active ingredient incorporated into a chewing gum and released by the mechanical action of chewing. The first Medicated chewing gum product.‘ Aspergum’, which contained acetyl salicylic acid for headaches, was launched in 1928. Medicated chewing gum is a good vehicle for administering active ingredients in pharmaceuticals and nutraceuticals. It offers a highly convenient, patient-compliant way of dosing medications, particularly for people with swallowing difficulties such as children and the elderly. It is also an ideal dosage form for drugs that help cure or relieve oral diseases, including toothache, periodontal disease, bacterial and fungal infections, and aphthous and dental stomatitis. Medicated chewing gum containing chlorhexidine is used to treat inflammatory conditions such as gingivitis. Using the medicated chewing gum formulation, the revitalization of old products and the reformulation of new patented products will differentiate them from upcoming generics competition. Thus, the potential of Medicated chewing gum for direct systemic delivery with higher patient compliance, its fast onset of action and the opportunity for product-line extension make it a likely drug delivery system. Keywords- Medicated chewing gum (MCG), periodontal disease, gingivitis, patient compliance

  Aceclofenac is a non-steroidal anti-inflammatory, analgesic and antipyretic drug used in the treatment of rheumatic arthritis, post-traumatic pain, masculo-skeletal and joint disorder. Problem with this drug is poor solubility in water hence poor bioavailability after oral administration. The objective of the research work was to develop and evaluate mouth dissolving tablets of Aceclofenac by using sublimation technique. The sublimation technique is used to increase the porosity of the tablets in which camphor was used as subliming agents which in turn forms the porous structure on the surface of tablets after sublimation. Aspartame was used as sweetening agent. The formulated tablets were evaluated for different parameters like weight variation, hardness, friability, drug content, disintegration time, wetting time, water absorption ratio, and In-vitro dissolution studies. Based on the results, formulation F-3 & F-6 containing Crosprovidon and Kyron T-314 10% concentration as superdisintegrants showed the least wetting time of about 17 & 13 sec, disintegration time of 25 & 18 sec and drug release of about 89.13 & 99.14% within 180 sec respectively and was found to be promising and selected as the optimized formulations. From the results, it was concluded that mouth dissolving tablets with improved Aceclofenac dissolution could be prepared by sublimation of tablets containing suitable subliming agent. Key words: Aceclofenac, mouth dissolving tablets, in-vitro, sublimation technique.