Shashank Nayak N

Fast dissolving tablets are the tablets which dissolves rapidly and shows higher bioavailability than conventional tablets. The concept of formulating Fast dissolving tablets of Carvedilol (antihypertensive drug) offer suitable and practical approach in serving the desired objective of faster disintegration and dissolution characteristic with increase bioavailability and to know the effects of two natural superdisintegrants (Hibiscus Rosa, Linseed Mucilage). In the present work solid dispersion were prepared by solvent evaporation method for improving the bioavailability with beta cyclodextrin as a carrier to increase the solubility of the drug. And after compressing the tablet , heat is applied to create pores in tablet as it contain camphor as subliming agent which increase the porosity and cause faster release of drug from the tablet. Comparison between these two natural superdisintegrants was done by taking different ratios individually and in combination. Combination of these two superdisintegrants shows synergistic effect when it is compared to individually. Prepared tablets were subjected to different evaluation parameters such as hardness, friability, weight variation, drug content uniformity, in vitro disintegration time, wetting time, in vitro dissolution studies and stability studies are carried out by using the best formulation. From all the formulations prepared and tested, F11 was found to be the best formulation.

Fast dissolving tablets are the tablets which dissolves rapidly and shows higher bioavailability than conventional tablets. The concept of formulating Fast dissolving tablets of Loratadine (antiallergic drug) offer suitable and practical approach in serving the desired objective of faster disintegration and dissolution characteristic with increase bioavailability and to know the effects of three synthetic superdisintegrants (Crosscarmeloss sodium, Sodium starch glycolate and Crospovidone). In the present work two methods of solid dispersion were compared for improving the bioavailability i.e Solvent Evaporation and Fusion method with beta cyclodextrin as a carrier to increase the solubility of the drug. Comparison between these three synthetic superdisintegrants was done by taking different ratios individually and in combination. Combination of these three superdisintegrants shows synergistic effect when it is compared to individually. Prepared tablets were subjected to different evaluation parameters such as hardness, thickness, friability, weight variation, drug content uniformity, in vitro disintegration time, wetting time, in vitro dissolution studies and stability studies are carried out by using the best formulation. From all the formulations prepared and evaluated F11 was found to the best formulation. Key words: Fast dissolving tablets, Solid dispersion, Crosscarmeloss sodium, Sodium starch glycolate, Crospovidone, Evaluation parameters.

Periodontitis is an inflammatory response to the overgrowth of anaerobic pathogenic organisms such as spirochetes and bactericides in the sub gingival plaque. If it is unchecked, results in the destruction of the bone and soft tissues supporting to the tooth, which leads to tooth loss. For treatment of these diseases we are preparing local drug delivery system of Levofloxacin dental strips. This helps to get local as well as sustained action against organism. Here we are used HPMC and ethyl cellulose as rate controlling polymer and dibutyl phthalate as plasticizers. Which shows tensile strength varies from 1.55-1.87 kg/cm2,the thickness varies from 0.33±0.002mm to 0.38±0.008mm. The weight variation and drug content was found to be uniform in all the formulation and folding endurance was found to be more than 200 in all the strips. In vitro dissolution was carried out by using static dissolution method and in vitro anti- bacterial activity was carried out by E.coli and S.aureus the zone of inhibition was calculated. The stability study was carried out under accelerated condition to found out the stability of all the formulation.

Medicated chewing gum (MCG) is a drug delivery system that consists of an active ingredient incorporated into a chewing gum and released by the mechanical action of chewing. The first Medicated chewing gum product.‘ Aspergum’, which contained acetyl salicylic acid for headaches, was launched in 1928. Medicated chewing gum is a good vehicle for administering active ingredients in pharmaceuticals and nutraceuticals. It offers a highly convenient, patient-compliant way of dosing medications, particularly for people with swallowing difficulties such as children and the elderly. It is also an ideal dosage form for drugs that help cure or relieve oral diseases, including toothache, periodontal disease, bacterial and fungal infections, and aphthous and dental stomatitis. Medicated chewing gum containing chlorhexidine is used to treat inflammatory conditions such as gingivitis. Using the medicated chewing gum formulation, the revitalization of old products and the reformulation of new patented products will differentiate them from upcoming generics competition. Thus, the potential of Medicated chewing gum for direct systemic delivery with higher patient compliance, its fast onset of action and the opportunity for product-line extension make it a likely drug delivery system. Keywords- Medicated chewing gum (MCG), periodontal disease, gingivitis, patient compliance