superdisintegrants

For more patient compliance there is a great demand for novel dosage form. Fast dissolving drug delivery system offers a solution for the patients who prefer oral route of drug administration without difficulty in swallowing. Fast dissolving films offers the simplest route of administration which is not painful and which do not require water for swallowing. Chlorpheniramine maleate is the First Generation alkyl amine antihistamine and used to relieve symptoms of allergy, hay fever, and common cold. These symptoms include rashes, watery eyes, itchy eyes/nose/throat/skin, cough, runny nose, and sneezing. In present study the aim was to formulate and evaluate fast dissolving films of Chlorpheniramine maleate. The films was prepared by solvent casting method, the superdisintegrants Crospovidone (2,4,6,8,10% w/w) and Microcrystalline Cellulose (5,10,15,20,25% w/w) were used in different concentrations with HPMC & PVA as a film forming base. Along with polymers and superdisintegrants the plasticizer PEG, mint flavor and sucrose were used in preparation of films. The formulated films were evaluated for thickness measurement, weight variation, folding endurance, disintegration time, in vitro drug release. It was concluded that the films containing Crosspovidone shows better drug release and less disintegration time as compared to the films containing Microcrystalline Cellulose.

A recent advance in Novel Drug Delivery System (NDDS) aims to enhance safety and efficacy of drug molecule by formulating a convenient dosage form for administration and to achieve better patient compliance. Mouth dissolving tablets or fast dissolving tablets have received ever-increasing demand during the last decade, and the field have been rapidly growing in  the pharmaceutical industry and gaining popularity due to ease of administration  and better patient compliance to all age groups. MDDDS have the unique property of dissolving and/or rapidly disintegrating and releasing the drug as soon as they come in contact with saliva, thus obviating the requirement of water during administration. This review focusses on various formulations and also technologies developed to achieve fast dissolution/dispersion of tablets in the oral cavity. The target population for these new fast dissolving/ disintegrating dosage forms have generally been pediatric, geriatric, and bedridden or developmentally disabled patients. Patients with persistent nausea, who are in traveling, or who have little or no access to water are also good candidates for MDDTs.