Chlorpheniramine maleate

For more patient compliance there is a great demand for novel dosage form. Fast dissolving drug delivery system offers a solution for the patients who prefer oral route of drug administration without difficulty in swallowing. Fast dissolving films offers the simplest route of administration which is not painful and which do not require water for swallowing. Chlorpheniramine maleate is the First Generation alkyl amine antihistamine and used to relieve symptoms of allergy, hay fever, and common cold. These symptoms include rashes, watery eyes, itchy eyes/nose/throat/skin, cough, runny nose, and sneezing. In present study the aim was to formulate and evaluate fast dissolving films of Chlorpheniramine maleate. The films was prepared by solvent casting method, the superdisintegrants Crospovidone (2,4,6,8,10% w/w) and Microcrystalline Cellulose (5,10,15,20,25% w/w) were used in different concentrations with HPMC & PVA as a film forming base. Along with polymers and superdisintegrants the plasticizer PEG, mint flavor and sucrose were used in preparation of films. The formulated films were evaluated for thickness measurement, weight variation, folding endurance, disintegration time, in vitro drug release. It was concluded that the films containing Crosspovidone shows better drug release and less disintegration time as compared to the films containing Microcrystalline Cellulose.

The proposed method is a simple, accurate, precise, specific and rapid method for the simultaneous estimation of dextromethorphan hydrobromide (DXM) and chlorpheniramine maleate (CPM) in bulk and syrup formulation. Stationary phase consist of Eclipse-XDB C18 column(150×4.6mm, 5μm) and mobile phase with gradient mode consisting of phosphate buffer (adjusted to pH 3.0 with o-phosphoric acid): acetonitrile (80:20 v/v) was used. The flow rate was set at 1.0 ml/min and UV detection was carried out at 272 nm. The retention time of DXM and CPM were 9.05 min and 7.53 min respectively. The % recovery of DXM and CPM was found to be 99.58 ±1.33 and 98.24 ±1.97 respectively. DXM and CPM drugs were found to be linear over the concentration range of 2-50 µg/ml and 0.8 - 20 µg/ml respectively. The proposed method can be useful in the quality control of DXM and CPM in bulk drug and drug products.