mucoadhesive

Target drug delivery is beneficial for the delivery of pharmaceutical product to its appropriate site and with the resurgence in the use of herbal therapies as health care medication and this new field of drug delivery holds intensive research. The purpose of the current study was to design, gastroretentive  mucoadhesive tablets using powdered leaves of Murraya koenigii and to optimize  a product using natural gums and their combinations. The gastroretentive, boiadhesive drug delivery prolongs the residence time of the dosage form at the site of absorption and facilitates an intimate contact of the dosage form with the underline absorption surface and thus contribute to improve and/or better therapeutic performance of the drug and shows promising future in enhancing the bioavailability and specific needs by utilizing the physiochemical characters of both the dosage form and the mucosal lining Gastroretentive, mucoadhesive tablets using powdered leaves of Murraya koenigii were prepared using direct compression method and evaluated for parameters such as Weight variation, Hardness, Friability, Drug content, Swelling index, In –vitro drug release study, In – vitro and In – vivo mucoadhesive strength. Different types of natural gums such as Carbopol, Hydroxypropyl methylcellulose (HPMC) and a gas – generating agent (Sodium bicarbonate) were used. The investigation shows that the tablet composition and mechanical strength have the greatest influence on the floating properties and the drug release. With the incorporation of a gas – generating agent, along with the polymers, increased optimum floating (floating lag time to 30 minutes, and the duration of floating > 8 hours ). The drug release was also increased and was sufficiently sustained (more than 8 hours) and non –Fickian transport of the drug was confirmed.

  Buccal delivery is considered to be an important alternative to the peroral route for the systemic administration of  drugs. The paper describes formulation of buccal mucoadhesive gel from Ficus carica mucilage using prorpranolol hyderochloride. Propranolol, a nonselective beta adrenergic blocking agent, has been widely used in the treatment of hypertension, angina pectoris, and many other cardiovascular disorders. It is highly lipophilic and is almost completely absorbed after oral administration. However, much of the drug is metabolized by the liver during its first passage through the portal circulation; on average, only about 25% reaches the systemic circulation. The conventional oral dosage form of this drug has low bioavailability due to high first pass metabolism, so it is modified as buccal drug dosage form to improve bioavailability and for the localized drug release because of high vascularity and drugs diffusing across the membrane have easy access to the systemic circulation via internal jugular vein. In present research mucilage is extracted from Ficus carica and studeuied for there mucoadhesive properties. The gel were evaluated by different parameters such as zeta potential, viscosity, Gel strength, Drug Release, Mechanism of drug release & histological study.