hepatoprotective

Michelia champaca, a healthful plant and it's normally utilized in people medication to treat varied diseases. The aim of the study was to evaluate the hepatoprotective & invivo antioxidant activities of Michelia champaca against carbon tetrachloride induced liver injury in rats. The methanol extract of Michelia champaca at dose of 250 and 500 mg/kg were administered orally once daily for seven days. Serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), total bilirubin (TB), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and total protein (TP) were estimated from serum. In-vivo antioxidant activity of methanol extract of Michelia champaca was evaluated by various assays including catalase (CAT), superoxide dismutase (SOD), reduced glutathione, glutathione peroxidase (GPx), glutathione reductase (GRD) and malondialdehyde (MDA) levels in liver tissues. Histopathological examination of the liver sections was carried out to support the induction of hepatotoxicity. The results of the study indicated that, methanol extract of Michelia champaca 500 mg/kg showed a major decrease in SGPT, SGOT, TB, ALP, LDH levels that were all elevated within the carbon tetra chloride treated group. The Michelia champaca extract showed considerably redoubled the degree of CAT, SOD, GSH, GPx, GRD and reduce the degree of MDA. Michelia champaca leaves extract therapy also protective effects against histopathological alterations. From the above study it can be concluded that methanol extract of Michelia champaca had hepatoprotective & antioxidant activities against carbon tetra chloride induced hepatic damage in experimental animals.

The hepatoprotective activity of the aqueous extracts of S. venulosa (AESV) and S. wallichiana (AESW) leaves on carbon tetrachloride (CCl4)-induced liver damage in albino rats was investigated. Animals were pretreated with the AESV (250 and 500 mg/kg body weight) and AESW (250 and 500 mg/kg body weight) for 15 days and then challenged with CCl4 (1 ml/kg body weight) in olive oil (1:1 v/v) on the 15th day. The degree of protection was measured by using biochemical parameters such as serum glutamate oxalate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), total protein and total bilirubin. Further the effects of both the extracts on catalase (CAT), peroxidase (Px) and superoxide dismutase (SOD) were estimated in both CCl4 treated and extract treated groups. Oral administration of AESV and AESW (500 mg/kg body weight) significantly protected from CCl4-induced elevation in SGOT, SGPT, ALP, total bilirubin, total protein and decrease in the activities of hepatic antioxidant enzymes namely SOD, CAT and Px. The extracts (AESV and AESW at 500 mg/kg body weight) also protected against histopathological damage induced by CCl4 such as distorted hepatocytes and necrosis. The present study suggests that AESV has potent antioxidant and hepatoprotective activity when compared to AESW. Key words: Schefflera species, hepatoprotective, CCl4, antioxidant enzymes.

Andrographis paniculata (Kalmegh, family: Acanthaceae) is used extensively in the Indian traditional system of medicine as a hepato-protective and hepato-stimulative agent. Osmotic drug delivery systems are the best amongst promising strategy based reliable drug delivery systems employed for controlled drug delivery. Floating drug delivery systems is one of the important approaches to achieve gastric retention to obtain sufficient drug bioavailability. Pre-formulation studies are the first step in the rational development of dosage form of a drug substance. Different quantities of cetosteryl alcohol ranging from 50 mg to 200 mg have been checked for floating lag.

The present study investigated the hepatoprotective activity of methanolic rhizome extract of Curculigo orchioides (MECO) in CCl4-induced hepatotoxicity model in rats. The hepatoprotective activity of methanolic rhizome extract of Curculigo orchioides were evaluated against CCl4-induced hepatic damage in rats. The three doses of MECO (100, 200 and 400 mg/kg) were administered orally once daily for seven days. Serum glutamate oxaloacetate transaminase (AST), serum glutamate pyruvate transaminase (ALT), serum alkaline phosphatase (ALP) and total bilirubin were estimated along with the estimation of superoxide dismutase (SOD) and malondialdehyde (MDA) levels in liver tissues. Further histopathological examination of the liver sections was carried out to support the induction of hepatotoxicity and hepatoprotective efficacy. The extract revealed significant activities and substantially elevated serum enzymatic levels of AST, ALT, ALP and total bilirubin were found to be normalized significantly by the MECO in a dose dependent manner with maximum hepatoprotection observed at 400 mg/kg dose level. The histopathological observations also indicated the biochemical evidences of hepatoprotection. Elevated level of superoxide dismutase (SOD) and decreased level of malondialdehyde (MDA) further affirmed the hepatoprotective observations. The results of the present study demonstrated that MECO have potent hepatoprotective activity against CCl4-induced hepatic damage in experimental animals.

The methanolic extract of Alstonia scholaris (L) R.Br. stem bark was screened for hepatoprotective activity against Swiss albino rats with liver damage induced by carbon tetrachloride. The results of hepatoprotective activity revealed that the methanolic extract of Alstonia scholaris significantly decreased the biochemical parameters (SGOT, SGPT, ALP, TP and TB). Silymarin (25 mg/kg), a known hepatoprotective drug, was used for comparison. The extract did not show any mortality up to a dose of 2000 mg/kg body weight. The findings indicated that the methanolic stem bark extract of Alstonia scholaris (L.) R.Br. (200 mg/kg) was effective in bringing the functional improvement of hepatocytes. The hepatoprotective activity was also supported by histopathological studies of liver tissues. Key words:  Alstonia scholaris, extract, hepatoprotective, carbon tetrachloride.

  Strychnos potatorum also known as clearing-nut tree is spread throughout the tropical and sub-tropical regions of the world. It has been highly reported in Ayurveda, Siddha and Unani systems of medicine. Some of the chief constituents found in the plant are strychnine, diaboline, isomotiol, sitosterol, stigmasterol and compresterol. The plant has been exclusively used as antimicrobial, nephroprotective, antidiabetic, antiarthritic, anti-inflammatory, antidiarrhoeal, hepatoprotective, antiulcerogenic, antinociceptive, antipyretic and contraceptive. Traditionally, it has been also used as stomachic, demulcent and emetic. The plant is also utilized for the treatment of various eye diseases, respiratory diseases, kidney complaints, and gonorrhea. The seeds of the tree are commonly used in traditional medicine as well as purifying water in India and Myanmar. This review paper briefly discuss the botany, ethnomedicinal, pharmacological and therapeutic applications of Strychnos potatorum with an attempt to compile the document and highlight the need of research and development.