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American Journal of PharmTech Research

Keyword

extract

Explore 5 research publications tagged with this keyword

5Publications
21Authors
4Years

Publications Tagged with "extract"

5 publications found

2021

1 publication

Phytochemical investigation of Cissus aralioides stems from Côte d’Ivoire

KOUASSI Affoué Delphine et al.
6/1/2021

As part of research on plants of interest for the floristic biodiversity of Côte d'Ivoire, a phytochemical investigation of the stems of Cissus aralioides, a species with medicinal properties of the botanical family Vitaceae, was produced. The mineral and organic compositions of said extract were determined, respectively by X-ray fluorescence spectrometry and by GC-MS. Elemental chemical analysis revealed considerable levels of trace elements (Fe, Mn, Zn), macro elements (Ca, Mg, P, K), and the presence of other elements (Ba, Ti, La, Cs, Rb, Ta, Cd). Analysis by GC-MS shows the existence of several active ingredients such as phenol acids, flavonoids, stilbenes and phytosterols. A major phytosterol (E-resveratrol) has been isolated from C. aralioides growing in Ivory Coast.

2020

1 publication

Prolonged Nutmeg Extract Usage As Potent As Glibenclamide In Diabetes Treatment

Jimmy EO and Effiong IE
8/1/2020

Comparative antidiabetic potentials study of the effect of ethanolic and aqueous extract of readymade nutmeg with glibenclamide was carried out on thirty (30) male and female albino rats and thirty (30) male and female albino mice for the period of 7, 14, 21 and 35 days. The animals were given low, medium and high doses of extract and 5mg/kg per body weight of glibenclamide for the period. The group administered with high dose of extract of nutmeg had significant  reduction in blood glucose level than (p<0.05), control. The aqueous extract of nutmeg showed significant reduction in blood glucose level on the days with low dose (p<0.05)  compared to control. A combination of nutmeg extract and glibenclamide showed a drastic significant (p<0.05) reduction in blood glucose level. The LD50 of the extract was 2738.1 mg/kg. The phytochemical analysis of the extract showed the presence of alkaloids, flavonoid, tannins, cardiac glycosides and saponins. But flavonoid concentration was very significant. It is showed in the study that prolong usage of aqueous extract of readymade nutmeg is very potent as glibenclamide in the treatment of diabetes. However, ethanolic extract of nutmeg showed higher potency than aqueous extract in the study. Key words: Ethanolic, aqueous, extract, nutmeg, glibenclamide, diabetes.

2014

1 publication

Preliminary phytochemical screening and inorganic element analysis of rhizomes of curcuma leucorhiza roxb.

Th.Sharatchandra Singh et al.
8/1/2014

The present paper deals with the phytochemical screening and Inorganic elemental analysis of the plant materials. Curcuma leucorhiza belongs to the family zinziberacea and has been used in folklore medicine to treat various ailments. . The rhizomes of curcuma leucorhiza are used for the treatment of enlarged liver spleen and stomach ulcer. The decoction of its rhizomes is used in the treatment of diabetes and cancer in local traditional medicines .The biological activities of curcuma leucorhiza include antioxidant activity, antibacterial activity and antifungal activity. The  rhizome parts of curcuma leucorhiza was slice,dried,grind into powder and then extracted with acetone, chloroform, methanol and ethanol solvents giving 9.06,12.90,7.30 and 13.20% yield respectively.  Phytochemical studies of the extracts showed the presence of terpenoids, alkaloids, saponins, flavonoids, glycosides, carbohydrates, phenolic, tannins, phytosterols, anthocyanin, proteins and amino acids etc. Quantitative determination of alkaloid was done by Harborne (1973) method. Inorganic elements are determined by a Graphite Furnace Atomic Absorption Spectrometer. Rhizome of curcuma leucorhiza contains minerals such as Fe, Zn, Cu, Mo, Cr, Mn and were found to be 0.971, 0.414, 1.70, 0.013, 5.091 and 0.015 ppb respectively  The results obtained shows that the extracts contain bioactive compounds and also trace element present in the plant extracts were within the permissible limits. The study will provide referential information for the treatment of various diseases.

2012

2 publications

Hepatoprotective Activity of Methanolic Extract of Stem Bark of Alstonia Scholaris (l.) R.br.

Ashutosh Kumar et al.
4/1/2012

The methanolic extract of Alstonia scholaris (L) R.Br. stem bark was screened for hepatoprotective activity against Swiss albino rats with liver damage induced by carbon tetrachloride. The results of hepatoprotective activity revealed that the methanolic extract of Alstonia scholaris significantly decreased the biochemical parameters (SGOT, SGPT, ALP, TP and TB). Silymarin (25 mg/kg), a known hepatoprotective drug, was used for comparison. The extract did not show any mortality up to a dose of 2000 mg/kg body weight. The findings indicated that the methanolic stem bark extract of Alstonia scholaris (L.) R.Br. (200 mg/kg) was effective in bringing the functional improvement of hepatocytes. The hepatoprotective activity was also supported by histopathological studies of liver tissues. Key words:  Alstonia scholaris, extract, hepatoprotective, carbon tetrachloride.

Study of wound healing activity of Delonix regia flowers in experimental animal models

M ohd Asif Khan et al.
4/1/2012

Delonix regia, a well known plant with high medicinal value, reported to have a number of biological activities including antioxidant, and presence of flavonoids in its chemical constituents. Antioxidant property and flavonoids have been associated with wound healing actions of plants. The present study was done to investigate the wound healing properties of Delonix regia in experimental animal models. The ethanolic and aqueous extracts of Delonix regia flowers were prepared to study the effect on wound healing in albino rats using incision and excision wound models. Healing was assessed by the rate of wound contraction, period of epithelialisation, tensile strength (skin breaking strength) and estimation the hydroxyproline content. The extracts significantly promoted the healing process, as evident by an increase in wound breaking strength, percentage of wound contraction, increased hydroxyproline content and decreased epithelialisation period, suggesting the possible utilization of this plant to enhance wound healing. Key words: Delonix regia, flowers, extract, wound.

Keyword Statistics
Total Publications:5
Years Active:4
Latest Publication:2021
Contributing Authors:21
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