extracts

Type 2 diabetes occurs when the body becomes resistant to insulin or doesn't make enough insulin. The major treatment approach for diabetes is the use of synthetic drugs and insulin. However the side effects associated with the use of synthetic agents attracts the attention of drug discovery professionals to search an effective treatment using natural products. Malaysian plants and herbs have been used as medicinal agents and studies have proved their significance in the treatment of diabetes.  As the fruits of Gnetum gnemon (family: Gnetacea) locally known as melinjo are traditionally used to control diabetes by Malaysian and Indonesian tribes, the present study was aimed to evaluate the folklore claim about G. gnemon fruits to treat diabetes. Hexane extract (GGHE), chloroform extract (GGCE), ethanol extract (GGEE) and water extract (GGWE) were obtained by successive extraction using soxhlet extractor. The preliminary phytochemical analysis was carried out to perceive phytoconstituents in G. gnemon extracts. Diabetes was induced in albino rats by single dose of streptozotocin (60 mg/kg b.wt. i.p.) followed by nicotinamide (120 mg/kg b.wt. i.p.). Streptozotocin-induced diabetic rats were separately treated with GGHE, GGCE, GGEE and GGWE at dose of 400 mg/kg b.wt. and standard drug, glibenclamide (10mg/kg) respectively by oral administration for 14 days and antidiabetic potential of the extracts were assessed. Prelimary phytochemical screening showed the presence of flavonoids, terpenoids, phenolic compounds and tannins. Oral administration of diabetic rats exhibited significant (P

The plant based antidiabetic remedies are gaining popularity throughout the world. There is large number of medicinal plants which are traditionally used for the management of diabetes. These plants need detailed investigation for the quality and quantity of the concerned chemical compounds. The present review has highlighted 81 plant species belonging to 12 families and 68 genera. Amongst the various plant parts of these species, leaves have been utilized in almost 50% of the total medical preparations. Other plant parts also have their utility in antidiabetic formulations. This information is useful for the herbal practitioners, biomedical researchers and pharmaceutical industries.

  Peucedanum grande is a succulent herb; about a meter in height. The fruits are used in medicine and have been reported to possess important biological properties. The objective of the present investigation was the development of quality standards and phytochemical analysis of P. grande. This included morphological and histological characters, pH of aqueous solution, ash values, extractive values, successive extractive values, and loss on drying, fluorescence analysis, preliminary phytochemical screening and HPTLC finger printing profile of secondary metabolites. The findings of this study might be useful to supplement information in regard to its identification parameters and laying down pharmacopoeial standards; as standardization of herbal medicines is essential and is the need of the today. Key words: Peucedanum grande, extracts, phytochemical screening, HPTLC.