dosage form

Modafinil is a wakefulness - promoting agent  (or eugeroic) used for treatment of disorders such as narcolepsy, shift work sleep disorder, and excessive  daytime sleepiness associated with obstructive sleep apnea.  It is sold under the brand names Alertec, Modavigil, and Provigil. Various analytical methods used for the estimation of Modafinil have been reviewed in this paper. These include Ultraviolet Spectrophotometry, RP-HPLC, Stability indicating RP-HPLC, HPTLC, Capillary zone electrophoresis, simultaneous determination by HPLC, LC-MS/MS, Liquid –liquid extraction,  HPLC , bidimensional HPLC, GC-MS and Solid-phase extraction followed by HPLC  in rat serum and urine  to determine the amount of Modafinil in bulk drug, pharmaceutical dosage form and biological fluids. These analytical methods can be used for qualitative and quantitative estimation of Modafinil in bulk, formulation and biological fluids.

Present  study  describes  the  spectrophotometric  method  development  and  subsequent  validation  of  dolutegravir  with  greater  precision  and  accuracy.  AIDS  is  the  most  dreadful  disease  in  the  society;  this  has  a  very  high  mortal  rate  among  the  countries,  as  results  loosing  many  beneficial  personalities.  There  are  many  antiviral  and  antiretroviral  drugs,  brought  forward  by  many  efficient  scientists. A  simple,  accurate,  novel,  safe,  and  precise  method  could  be  developed  for  the  estimation  of  Dolutegravir.  Spectrophotometric  measurements  were  carried  out  using  Schimadzu    double  beam(UV-1800  model)  Ultra  violet  visible  spectrophotometer  with  10mm  matched  quartz  cells  and  water  as  solvent. Linearity  for  the  method  was  found  in  the  range  of  2-14μg/ml  (r2=0.997).  Tablet  formulation  was  analyzed  and  %  assay  for  the  absorption  maxima  was  found  to  be  95.6%. The proposed method was validated as  per  ICH  guidelines.  Validated  studies  demonstrated  that  proposed  method  is  simple,  accurate,  precise,  specific,  rapid,  reliable,  and  reproducible.

Tramadol Hydrochloride is an opioid pain medication which is used to treat moderate to moderately severe pain. Various analytical methods used for the estimation of Tramadol hydrochloride has been reviewed in this paper. These include Ultraviolet spectrophotometry, Visible spectrometry, Spectrofluorimetry, High Performance Liquid Chromatography, Ultra Performance Liquid Chromatography, High Performance Thin Layer Chromatography, Gas Chromatography- mass spectrometry, Cyclic Voltammetry, Liquid Chromatography-Electronspray ionization-mass spectrometry, Gas Chromatography, Liquid Chromatography- mass spectrometry, and Capillary Electrophoresis to determine the amount of Tramadol Hydrochloride in bulk drug, pharmaceutical dosage form and biological fluids. Stability indicating methods for Tramadol Hydrochloride are also described. These analytical methods can be used for qualitative and quantitative estimation of Tramadol Hydrochloride in bulk, formulation and biological fluids.