diclofenac potassium

In the current investigation we formulated and evaluates matrix tablet using modified gum of Pistacia lantiscus gum (PLMG) as natural matrix forming agent used in various successively increasing concentration. The pre-compression study of the powder blends of drug, PLMG and other excipients were done by calculating bulk density, tapped density, angle of repose and carr’s index (% compressibility) and hausner’s ratio. The tablets using PLMG as matrix forming agent were prepared by direct compression method and prepared tablets were evaluated for thickness, hardness, weight uniformity, friability and content uniformity and were found according to the official guidelines by pharmacopoeia. The swelling behavior of prepared matrix tablets was studied using for 12 hours at 37 ±0.2 0C, it was fond that the drug to modified gum ratio of 1:2 was found to be optimum swelling with the sustained release of model drug up to 97.12 in matrix tablet formulation. The results revealed, that modified fraction of Pistacia lantiscus gum can be used as a drug release modifier to delay as the rate of drug release of which depended on the amount of gum composition, as the concentration of gum was increased there was sustain the drug release.

The aim of this study was to prepare Diclofenac potassium (DP) microspheres by using Double Emulsion-solvent evaporation method with ethyl cellulose (EC) and Eudragit polymers. An attempt was made to formulate a sustained release dosage form of diclofenac potassium, to minimize frequent dosing as well as reducing or eliminating local side effects by avoiding the drug release in the upper gastro-intestinal tract Poly vinyl alcohol containing 2% (w/w) span 80 was the external phase and polymer -drug solution was the internal phase. EC and Eudragit were used to encapsulate diclofenac potassium. By using different formulation variables, six different formulations (F1, F2, F3, F4, F5, & F6) were prepared. The resulting microspheres obtained, were more spherical in shape and showed more entrapment efficiency. The size of the microspheres varied between 346-695 μm and as high as 96.24% loading efficiency for Eudragit and 82.34% for EC was obtained. In vitro release study was carried out in 0.1 N hydrochloric acid solution (pH 1.2) for first 2 hours followed by in phosphate buffer solution (pH 6.8) for next 4 hours. After first 2 hours of dissolution in 0.1 N hydrochloric acid, EC microspheres released 23% of drug and Eudragit released 7% of drug. The formulations were found to be effective in providing controlled release of drug for a longer period of time.