Vitamin-C

Fucidin, a topical antibacterial agent indicated in the treatment of bacterial infections. It works by interfering with bacterial protein synthesis, specifically by preventing the translocation of the elongation factor G (EF-G) from the ribosome. The aim of the present study was to prepare topical gel by using gel forming polymers along with chitosan and to study the effect of the concentration of polymers, effect of alone Fucidin, combined effect of Aloe Vera with vitamin C on different gel parameters and wound healing activity. The gel formulations were prepared by soaking method using Carbopol 934p as gelling agent/gel base. IR spectroscopy studies suggested that the formulations prepared is a physical mixture and the drug is compatible with other excipients. The prepared gel formulations were evaluated for drug content, pH and rheological parameters like viscosity, spreadability and extrudability. The percentage release of Fucidin from plain gel was slow as compared to other drug loaded gel formulations. The formulation (F8) showed maximum percentage release (99.56%). All the gel formulations showed more than 80% reduction in wound contraction. The gel formulation containing Fucidin along with 1% chitosan and 1% sodium alginate showed 99.4% reduction in wound area after 12 days.

In the present study, hepatoprotective effect of an ethanolic extract of Ipomoea batatas leaves, on liver injury induced by carbon tetrachloride (CCl4) was investigated. Wistar albino rats (n=6) were administered 300, 600 and 900 mg/kg body weight extract orally for 10 consecutive days. Marker enzymes SGOT, SGPT, serum protein and Bilirubin (total, direct and indirect) were estimated in serum whereas total protein (TP), Lipid peroxidation (LPO), superoxide dismutase (SOD) and catalase were estimated in liver tissue as markers for oxidative stress.  Histopathological assessment was also done on liver tissue. Ethanolic extract of Ipomoea batatas leaves administration for 10 days prevented the CCl4 induced hepatic injury and oxidative stress. Hepatoprotective effect of I. batatas in CCl4 induced liver poisoning was evident by decrease in elevated levels of SGOT, SGPT and bilirubin. Treatment with I. batatas increased the reduced levels of TP and SOD and decreased the elevated level of MDA concentration and catalase activity in CCl4 induced oxidative stress in the liver. The ability of ethanolic extract of Ipomoea batatas leaves to protect the liver toxicity in rats was further confirmed by histological findings in the liver tissue. In conclusion, it was observed that ethanolic extract of Ipomoea batatas leaves have a dose dependent potential to protect the liver against CCl4induced hepatic injury through its potent antioxidant activity in rats.