Titrimetry

Solubilization of poorly water‐soluble drugs has been a very important issue in screening studies of new chemical entities as well as formulation research. Hydrotropy is one of the solubility enhancement methods for aqueous solubility of poorly water-soluble compounds. Cefixime HCl is poorly water soluble drug which shows good aqueous solubility in 2 M Sodium Benzoate solution. For quantitative estimation of Cefixime HCl in bulk and tablet dosage form, a titrimetric analytical method and spectrophotometric methods has been developed using 2 M Sodium Benzoate as a hydrotrope. Hydrotropic solution was employed to solubilize a practically water insoluble drug, Cefixime HCl in bulk and tablet dosage form to carry out titrimetric and spectrophotometric analysis precluding the use of organic solvents. The bulk containing Cefixime HCl was analyzed successfully. Statistical data proved accuracy, reproducibility and the precision of the proposed method. The presence of hydrotropic agent Sodium Benzoate did not interfere in the analysis. The proposed methods are new, simple, accurate, reproducible and eco-friendly.