Sodium Benzoate

Current study was undertaken to improve solubility and bioavailability of poorly water soluble drug, Olmesartan. A mixed hydrotropic method was used to prepare the hydrotropes of Olmesartan. On the basis of screening Sodium Benzoate, Potassium Acetate and Tri Sodium Citrate hydrotropes were selected to prepare various hydrotropic solid dispersions of Olmesartan using selected hydrotropic agent in different ratio with the drug. The prepared solid dispersions were evaluated for solubility analysis, Drug Content Estimation, Fourier Transformed Infrared Spectroscopy, Differential Scanning Calorimetry, and In-vitro Dissolution Study of hydrotropes. From the study the results revealed that solubility was increased by using certain ratio (1:1:1:0.5) of drug with hydrotropic agents alone as well as in the combination. In the present study an attempt was made to prepare hydrotropes of a poorly water soluble drug Olmesartan to enhance the solubility and bioavailability of drug. The screening of different hydrotropic agents was performed to evaluate the best suited agent for drug hydrotrophs. On the basis of solubility analysis, the Sodium Benzoate, Potassium Acetate and Tri Sodium Citrate agents   have the ability to enhance the solubility of the drug more than 3 times of its original solubility. The method is economical and simple, to enhance the solubility of Olmesartan.

Solubilization of poorly water‐soluble drugs has been a very important issue in screening studies of new chemical entities as well as formulation research. Hydrotropy is one of the solubility enhancement methods for aqueous solubility of poorly water-soluble compounds. Cefixime HCl is poorly water soluble drug which shows good aqueous solubility in 2 M Sodium Benzoate solution. For quantitative estimation of Cefixime HCl in bulk and tablet dosage form, a titrimetric analytical method and spectrophotometric methods has been developed using 2 M Sodium Benzoate as a hydrotrope. Hydrotropic solution was employed to solubilize a practically water insoluble drug, Cefixime HCl in bulk and tablet dosage form to carry out titrimetric and spectrophotometric analysis precluding the use of organic solvents. The bulk containing Cefixime HCl was analyzed successfully. Statistical data proved accuracy, reproducibility and the precision of the proposed method. The presence of hydrotropic agent Sodium Benzoate did not interfere in the analysis. The proposed methods are new, simple, accurate, reproducible and eco-friendly.