Taste masking

In the present research work attempt was to formulate tasteless complexes of Ambroxol hydrochloride using cation exchange resins and to evaluate molecular properties of drug complexes. Tulsion 343 that contained crosslinkedpolyacrylic backbone was used. The drug loading onto ion-exchange resin was optimized for mixing time, activation, effect of pH, mode of mixing, ratio of drug to resin, and temperature. Drug resin complexes (DRC) were evaluated for taste masking and characterized by x-ray diffraction study and infrared spectroscopy.Ambroxol hydrochloride is a potent mucolytic agent capable of inducing bronchial secretion. It is used in the treatment of asthma, bronchitis and cough.It is a highly bitter drug and not suitable for pediatric patients hence taste masking of drug was required. Ambroxol hydrochloride-Tulsion 343 complex of ratio 1:0.7% w/w  was  developed into  suspension formulation  using different  suspending agents  with  varying concentration  and was evaluated for  sedimentation volume, pH, drug content  and viscosity. The prepared suspensions were evaluated for taste, drug content, particle size, viscosity, sedimentation volume, drug release. The results showed that Ambroxol Hydrochloride was successfully taste masked,showed easy redispersibility and more than 80% drug release within 45 minutes and when compared with  marketed preparation. Key words:Tulsion 343, Drug-resinate complex, Taste masking, Suspension

Many oral dosage forms, bulking agents and beverage products have unpleasant taste. The bitter taste is an undesirable trait of the product or formulations and can considerably affects its acceptability by consumer. So, they should be formulated in a palatable form. Bitter taste in such systems can be reduced or eliminated by various methods, but no universally applicable technologies are yet recognized. This article is about the discussion of recent approaches for minimizing the unpleasant taste for oral pharmaceuticals.   Key words: Taste masking, Eudragit.