Eudragit.

In the present study, an attempt was made to prepare and evaluate matrix tablets of Ondansetron HCl using HPMC, EC and Eudragit for Sustained release of Ondansetron HCl. The matrix tablets were prepared by wet granulation method. All the formulations are evaluated for the Hardness, Friability, Weight variation, Drug Content, In-Vitro Drug Release. The weight variation and drug contents of all the tablets were found to be uniform with the low SD values. The FTIR study indicated that the drug is stable in the formulations. The prepared matrix tablets were capable of releasing the drug for 12 hours depending upon the formulation variables. The tablets prepared with HPMC and Eudragit combination have shown higher drug release Drug release mechanism followed non-Fickian transport from both the polymers matrices. The drug released from the formulation is depends on the concentration of the polymers.

The aim of the present study is to prepare Tinidazole microspheres by using different polymers. Microspheres were prepared by solvent evaporation method by using various polymers. Formulation is optimized on the basis of acceptable microspheres properties and in-vitro release. In order to obtain best optimized product, 6 different formulations were developed. Different polymers like Eudragit S100, HPMC 6000 and HPC 1000 were taken as variables. Particle size analysis, Shape and Surface Morphology, Flow properties, Degree of swelling, Drug entrapment efficacy, Invitro drug release study were studied as response variables. The different physical properties showed best comparable results with drug. But higher percentage of drug release was observed when the formulation contained Eudragit S 1000 in 1:1 ratio(f3) compared to other formulations. The formulation contained Eudragit was selected as optimized product.

Many oral dosage forms, bulking agents and beverage products have unpleasant taste. The bitter taste is an undesirable trait of the product or formulations and can considerably affects its acceptability by consumer. So, they should be formulated in a palatable form. Bitter taste in such systems can be reduced or eliminated by various methods, but no universally applicable technologies are yet recognized. This article is about the discussion of recent approaches for minimizing the unpleasant taste for oral pharmaceuticals.   Key words: Taste masking, Eudragit.