Swiss albino mice

  Clerodendron serratum spreng is very much effective in preventing Dalton’s Ascetic Lymphoma cell in mice which was confirmed by evaluating the hematological parameters. Peritoneal cell count, solid tumors volume, body weight and histopathological studies. This holds great promise for future research in human beings. The anticancer properties of Clerodendron serratum spreng will provide useful information in the possible application in cancer prevention and cancer therapy. The treatment with ethanolic and aqueous extracts of Clerodendron serratum spreng significantly altered all the parameters, near to normal. Maximum alteration of parameters occurred in the group treated with the aqueous extract at the dose of 300 mg/kg/day.

  Benzo(a) pyrene (BP), the polycyclic aromatic hydrocarbon which is highly carcinogenic present in tobacco smoke causes lung cancer. So nowadays a lot of attention on plant based products which act as chemopreventive agents are used to prevent lung cancer. So the present investigation focuses on the Punica granatum which is a medicinal plant and used in folk medicines. The present investigation was carried out to determine the effect of ethyl acetate fraction of Punica granatum rind extract on tumor markers in benzopyrene induced lung cancer in Swiss albino mice. The analysis on tumor markers revealed that the ethyl acetate fraction of Punica granatum rind extract possess antineoplastic effect on lung cancer induced in Swiss albino mice which may be due to the highest percentage of Pyrogallol in the active fraction.   Key words: Punica granatum, Benzopyrene, Swiss albino mice, Lung cancer, Pyrogallol.