Statins

Pravastatin is widely used antihyperlipidemic drug, exhibits poor aqueous solubility and low dissolution rate, which limit its oral bioavailability. The present study focuses on the design, development and evaluation of the pravastatin solid dispersion tablets prepared by the direct comparison method to enhance dissolution efficiency. Solid dispersions were characterized by using the FTIR, Melting point Analysis, and calibration studies, while the flow properties such as bulk density, tapped density, angle of repose, Carr’s index were determined to ensure suitable compressibility.

Researches done on the use of statins during the last two decades have shown conflicting results in their effects on DM, Cardiac, liver and Kidney functions. Six forms of statins are being prescribed as a preventive measure to reduce the incidence of cardiovascular morbidity and mortality; but statin use have also shown alternations in DM, liver and Kidney function. The latest observations relates to cancer prevention/induction. Statins prescriptions are done mostly for elderly patients in order to reduce lipid profile mostly Total cholesterol and LDL levels. Studies have shown that statins use affects muscular function, induce prediabetes, and alter liver enzymes and affects mitochondrial functions. They may also interact with other medications. Some merits shown in the use of statins include prevention of MCI and strokes. Among the statins used, atorvastatin was found to be very beneficial with minimal side effects with greater beneficial function in maintaining other organ functions. This review article highlights the research findings on the use of statins and its merits and demerits during the last two decades. More clinical trials with large population are required to establish the type of statins to be required for each type of patients and clinical conditions.