Direct Compression method

Pravastatin is widely used antihyperlipidemic drug, exhibits poor aqueous solubility and low dissolution rate, which limit its oral bioavailability. The present study focuses on the design, development and evaluation of the pravastatin solid dispersion tablets prepared by the direct comparison method to enhance dissolution efficiency. Solid dispersions were characterized by using the FTIR, Melting point Analysis, and calibration studies, while the flow properties such as bulk density, tapped density, angle of repose, Carr’s index were determined to ensure suitable compressibility.