Rat caecal content.

  Matrix tablets of Indomethacin were prepared by wet granulation method. Guar gum as a carrier, 10% starch paste, HPMC, citric acid and the mixture of talc and magnesium stearate at 2:1 ratio were used. Coating was carried out by using 10% Eudragit L 100. All the prepared formulations were evaluated for hardness, drug content uniformity, stability study and were subjected to in vitro drug release studies in rat caecal contents. The highest in vitro dissolution profile at the end of 24 h was shown by IF6 followed by IF7, IF8. The other formulation IF4, IF3, IF2 and IF1 were failed to target in colon and these formulation releases the majority of drug within 10 h of study. It may be due to the less proportion of guar gum to retard the drug release.  The colon targeted matrix tablet of Indomethacin showed no change either in physical appearance, drug content or in dissolution pattern after storage at 30˚ C/ 65±5 % RH for 2 months.   Key words: Colon targeted, Eudragit L-100, Guar gum, Indomethacin, Matrix tablets, Rat caecal content.