Indomethacin

The Piper chaba ethanolic extract showed protection against characteristic lesions produced by ulcer due to Indomethacin administration. This gastroprotective effect of Piper chaba ethanolic extract may be due to both reductions in gastric acid secretion and gastric cytoprotection which may further contribute in the treatment of peptic ulcers. Indomethacin produces necrotic lesions in the gastric mucosa by reducing the secretion of bicarbonate and production of mucus, increasing vascular permeability and decreasing non-protein sulfhydryl groups of gastric mucosa. Indomethacin rapidly penetrates the gastric mucosa apparently causing cell and plasma membrane damage leading to increased intracellular membrane permeability to sodium and water and thus causing gastric mucosa damage. Suppression of prostaglandins synthesis by ethanol results in increase susceptibility of the stomach to mucosal injury and gastro duodenal ulceration. The Piper chaba ethanolic extract significantly reduced ulcer index. The Piper chaba ethanolic extract showed protection against characteristic lesions produced by ulcer due to Indomethacin administration. This gastroprotective effect of Piper chaba ethanolic extract may be due to both reductions in gastric acid secretion and gastric cytoprotection which may further contribute in the treatment of peptic ulcers.

Indomethacin is a drug belongs to class NSAIDs used in the treatment of inflammatory rheumatoid diseases and relieve acute pain, period pain and pain after surgery and fever. This study aimed at evaluating some quality control parameters to compare the quality, safety, and efficacy of three brands of Indomethacin capsules available in the Indian market. In the present study three marketed formulations of Indomethacin of 25 mg strength were analyzed with quality parameters like Weight variation test, Disintegration test and In-vitro bioequivalence study with developed spectrophotometric analytical method. The Indomethacin capsule, Microcid exhibited highest in-vitro drug release 97.05% and lowest Disintegration time 320 sec. compared to other brands of Indomethacin capsule.  

  The medicinal plants have been selected for thorough studies from indigenous folk medicines, Ayurvedic, Unani and Siddha systems of medicines. Ficus bengalensis Linn (Moraceae) is a plant that is widely distributed in India. In traditional medicines it is used for healing obstruction of urine flow, diarrhea, dysentery, conjunctivitis, scabies and diabetes. So it has been a subject of chemical, biological and pharmacological interest since a long time. The aqueous or alcoholic extracts of various parts of this plant were found to have various pharmacological activities for example, antidiabetic, hypocholesterolemic, hypolipidemic, anti-inflammatory, anthelmintic, antibacterial, antiallergic and anti-tumor activity. The anti-ulcer activity of a methanolic extract prepared from the stem bark of Ficus bengalensis Linn was evaluated in rats employing the ethanol-acid and Indomethacin models to induce experimental gastric ulcers. Treatments with Ficus bengalensis Linn methanolic extract (100, 200 and 400mg/kg) provided significant anti-ulcer protection in the ethanol-acid and Indomethacin models. Keywords: Anti-ulcer, ethanol-acid, Indomethacin, Ficus bengalensis Linn, dysentery

  Matrix tablets of Indomethacin were prepared by wet granulation method. Guar gum as a carrier, 10% starch paste, HPMC, citric acid and the mixture of talc and magnesium stearate at 2:1 ratio were used. Coating was carried out by using 10% Eudragit L 100. All the prepared formulations were evaluated for hardness, drug content uniformity, stability study and were subjected to in vitro drug release studies in rat caecal contents. The highest in vitro dissolution profile at the end of 24 h was shown by IF6 followed by IF7, IF8. The other formulation IF4, IF3, IF2 and IF1 were failed to target in colon and these formulation releases the majority of drug within 10 h of study. It may be due to the less proportion of guar gum to retard the drug release.  The colon targeted matrix tablet of Indomethacin showed no change either in physical appearance, drug content or in dissolution pattern after storage at 30˚ C/ 65±5 % RH for 2 months.   Key words: Colon targeted, Eudragit L-100, Guar gum, Indomethacin, Matrix tablets, Rat caecal content.