Poly vinyl alcohol

The main objective of this study is to improve the physicochemical stability, swelling and drug release pattern of the polymers in biological condition by Hybridization. In this study, interpenetrating polymer network (IPN) of acrylamide grafted ghatti gum (Am-g-GG) and poly vinyl alcohol (PVA) was developed by emulsion crosslinking method. Glutaraldehyde was used as the crosslinking agent. Experiments were performed according to a 23 factorial design to evaluate the effects of GG:PVA ratio, Glutaraldehyde and drug loading percentage on the percent Drug entrapment efficiency, percentage of Swelling at pH 1.2 & pH 6.8 and percentage Cumulative drug release. The effect of the three independent variables on the response variables was studied by response surface plots and contour plots generated by the Design-Expert software. The desirability function was used to optimize the response variables. The compatibility between Miglitol and the excipients was confirmed by differential FTIR spectroscopy analysis. The prepared IPN microspheres showed well controlled release characteristics and continued to drug release following a diffusion-controlled release pattern. The drug release was for a prolonged time without collapsing the IPN matrix. The observed responses taken were in good agreement with the experimental values. Thus, Miglitol IPN microspheres were produced with fewer experimental trials, and a patient compliant product with good stability was achieved with the concept of formulation by design.

In present study long-acting biodegradable Nateglinide loaded Poly (lactic-co-glycolic) acid nanoparticleformulation is reported for treatment of Type 2 Diabetes Mellitus (T2DM).Different formulations were prepared by varying drug: polymer ratio (1:1, 1:2, and 1:3) and polyvinyl alcohol as stabilizer in 0.5-1.5% concentration range by emulsificationsolventevaporation technique. Optimization was carried out by evaluating entrapment efficiency and particle size. Optimized formulation was characterized for in vitro drug release, surface charge property, SEM, chemical incompatibility and invivo evaluated for blood glucose lowering property in rat model. The obtained resultsindicatethat formulation composition containing drug:polymer ratio 1:3 and stabilizer concentration 1.5%  gives high encapsulation efficiency (82.15%) with mean particle diameter of 216 nm and drug release for 72h. Drug release data was best fitted to Higuchi model indicating drug release was mainly took place by diffusion mechanism. Oraladministrationof optimized nanoparticle formulation showed two fold better activity as compared to standardNateglinide formulation(P