Oral drug delivery

Gastro retentive drug delivery system is benefited system in which dosage form retained in stomach prolong period of time and drug release long period of time. Floating system means that float over the surface of the gastric contents when the stomach is full but at the time stomach is empties and the tablet reaches the pylorus the buoyancy of the dosage may be decrease & bioadhesive system becomes dislodged from the stomach wall when the system is full but a floating -bioadhesive system would overcome these drawback of floating and bioadhesive system and improving the therapeutic effect of the drug involved.   So this Floating-bioadhesive dosage forms exhibit a unique combination of floatation and adhesion for prolonged residence in the Stomach. Currently this floating bioadhesive approach is not only used for tablets but also for microsphere, beads & other dosage forms. This review article focus on recently used combination approaches to deliver drug by gastrointestinal drug delivery like Bioadhesive and floating.

One of the most feasible approaches for achieving prolonged and predictable drug delivery profiles in gastrointestinal tract is to control the Gastric Residence Time (GRT) using gastro retentive dosage forms (GRDFs) that offer a new and better option for drug therapy. Oral delivery of drugs is by far the most preferable route of drug delivery. Oral-rate controlled drug delivery systems have an important area among novel drug delivery system. But these oral sustained release drug delivery systems suffer greatly due to their short gastric residence time/ gastric emptying time. Whereas prolonged gastric residence increases duration of drug release, reduces drug waste, and improves drug solubility in gastric pH. In order to overcome these drawbacks novel dosage forms that can be retained in the stomach for a prolonged and predictable period of time were discovered and they successfully exists today as gastro retentive dosage forms, in academic and industrial research groups. The objective of our review is to compile the recent advancements and literatures regarding the novel dosage form i.e. the floating drug delivery systems (FDDS) that can be retained in the stomach for a prolonged period of time and gives therapeutic action in a predetermined manner. Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), swelling and expanding systems, polymeric bioadhesive systems, high-density systems, modified-shape systems and other delayed gastric emptying devices. In this review, current & recent developments of Stomach Specific FDDS are discussed. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail.