IR spectra

Purines and pyrimidine derivatives are the important class of compounds in medicinal chemistry. Pyrimidine – a totally unsaturated six membered ring containing nitrogen at 1,3-position. They represent the diazine family with urazil and thymine being the constituents of ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) and with cytosine. The work highlights one pot synthesis of some 1,3-dihydro pyrimidine derivatives from different substituted aldehydes. All the synthesized derivatives were screened for antibacterial activity using  gram positive (Bacillus subtilis, Staphylococcus aureus) and gram negative (Pseudomona aeruginosa, Escherichia coli) organisms at concentrations of 400μg/disc and 200μg/disc. The compound 5b (p-dimethyl aminophenyl derivative) was found to be sensitive in all strains. The structure of compound 5b was confirmed by IR spectral studies.

The present investigation is mainly on the synthesis, characterization and determination of some properties of new compound cetylpyridinium hexafluorosilicate for his potential use as caries-preventive and antibacterial agent. Hexafluorosilicate of the composition (C21H38N)2SiF6 was separated as crystalline product of interaction of hexafluorosilicic acid with the methanol solution of cetylpyridinium chloride. This complex was characterized by elemental analysis, IR, 1H and 19F NMR, mass-spectrometry, differential thermal analysis, and solubility data. The IR spectral data indicates on absence of noticeable distortion of the symmetry of SiF62– anion with regard to Oh. The studied compound is characterized by the predicted tendency to hydrolyze in dilute aqueous solutions with the formation of silica and fluoride anions.