Guggul

Herbal medicinal plants are the gift of nature to the human beings. The present review is an effort to give a detail literature survey and discovering the hidden Marvels of Commiphora wightii also its remarkable health benefits in human beings. Worldwide Commiphora wightii is also known as Guggul is known for its anti-inflammatory property. Along with these it has many pharmacological activities like in the treatment of Rhematoid arthritis, fibrinolysis, weight management, Cardioprotective action, thyroid function regulation, antioxidant support and in metastatis Inhibition. It contains various chemical constituents like guggulsterones, guggulipid, commiphoric acid, Monoterpenoids, guggultetrols, Steroids, flavonoids, diterpenoids, sesquiterpenoids, triterpenes, lignans and various amino acids which contribute to various therapeutic property.

The emerging new fixed dose combination of Glipizide (GLZ) as sustained release and Telmisartan (TEL) as immediate release were formulated as a bilayer matrix tablet using guggul. Guggul used as a binding agent with three different concentrations (70%, 80%, and 90%; F1-F6) was used for the preparation of first layer of tablet containing glipizide. The conventional tablet of telmisartan was prepared as a second layer. Prepared bilayer tablets were studied for the in vitro release study carried out at pH 1.2 for first two hours and then at pH 6.8 for 6 hours using USP dissolution apparatus II (Basket). All the evaluation tests were found to be within the acceptance limits specified in Indian Pharmacopeia. The assay and dissolution study of tablets were done by HPLC which was developed and validated according to the ICH Q2 (B) guidelines. The contents of assay of the tablets were found to be 90.92% - 103.84% for F2-F5. The release of glipizide from the tablet was extended up to 8 h. Tablet containing 2.5 mg of glipizide with 80% of guggul release of drug after 8 h was found to be 82.36% and tablet containing 5 mg of glipizide with 90% guggul release of glipizide after 8 h was found to be 74.67%. The release pattern of each formulation (F2-F5) was fitted into the dissolution kinetics models and all the formulations were best fitted in the Higuchi model kinetic. From the results, we have concluded that the guggul act as a binding agent as well as rate retarding agent.