Canthium parviflorum

The main aim of the study was to investigate phytoconstituents and anti-helminthic activity in the canthium parviflorum root. Roots were collected and shade dried. Extraction was carried out by continues hot percolation method using ethylacetate and methanol as solvents. Both the extracts were subjected to phytochemical screening, using standard methods, where as anti-helminthic activity was evaluated at three different concentrations on Pheretima Postuma; the parameters like time of paralysis and time of death were determined. The extract showed significant activity in the dose dependent manner and methanolic root extract showed significant activity than that of standard drug Albendazole. This might due to the presence of secondary metabolite tannins which are responsible for the activity.

The objective of the study was to evaluate the anticancer activity of Acetone root extract of Canthium parviflorum Lam. (ARECP) in N-Nitroso N-methyl urea (NMU) induced mammary carcinoma in female Sprague-Dawley rats. Thirty virgin female Sprague-Dawley rats of 55 day old were divided into five groups (normal control, disease control, ARECP 200 mg/kg, ARECP 400 mg/kg, tamoxifen10 mg/kg) of six animals each. The mammary carcinoma was induced by two intraperitoneal doses of N-Nitroso N-methyl urea (NMU) (50mg/kg/body weight each) in 0.9% Nacl (maintained at 40C) at 55 day of age and 4 week after the prior administration. The drug ARECP was administered in two doses, 200 mg/kg, and 400 mg/kg orally and compared with the oral dose of tamoxifen (10 mg/kg). ARECP 200 mg/kg, 400 mg/kg, and tamoxifen10 mg/kg decreased the tumor incidences by 33.33%, 50%, and 83.33% and the total number of tumors in group by 33.33%, 60% and 93.33% respectively, when compared to the disease control. ARECP 200 mg/kg, 400 mg/kg, and tamoxifen 10 mg/kg decreased the average tumor burden by 65.06%, 92.16% and 95.72% and average tumor volume by 62.25%, 85.18%, and 93.73% respectively, when compared to disease control group. The results concluded that ARECP prevent the mammary carcinogenesis induced by N-Nitroso N-methyl urea in female Sprague-Dawley rats.