Camphor

The objective of the study was to develop an oral controlled release drug delivery system of Lamivudine using the sublimation method. Camphor was used as the sublimation material to prepare gastro retentive tablets that are low-density and easily floatable. Camphor was changed to pores in the tablet during the sublimation process. Floating properties of tablets and tablet density were affected by the sublimation of camphor. Release profiles of the drug from the gastro retentive tablets were affected by tablet density/porosity. The effects of different formulation variables HPMC and the effects of different concentrations were studied. The in vitro evaluation was carried out and it was found that the drug release was affected by different concentrations of polymers used. The highest percentage of drug release (96.89±0.83) was observed with xanthan polymer and followed diffusion with erosion mechanism (Non-Fickian transport).

Oral analgesics are commonly prescribed  for the treatment of acute and chronic pain, but these  agents often produce adverse systemic effects, which some times are severe ,so topical administration of analgesics is an alternative method. The  aim of  present work is to develop semi solid preparations of natural analgesics like camphor. Three different strengths were prepared which are 25mg,50mg,100mg in two different bases that are hydrophilic and hydrophobic. All the prepared  formulations  were evaluated  for PH, spreadability, diffusion studies. The selected formulations were evaluated for in-vivo studies in comparison with marketed preparations .The  finalized preparation was kept for stability studies according to ICH guidelines. Keywords: Pain, Camphor, Ointment.