Formulation and Evaluation of Lamivudine Floating Tablets by Sublimation Method

The objective of the study was to develop an oral controlled release drug delivery system of Lamivudine using the sublimation method. Camphor was used as the sublimation material to prepare gastro retentive tablets that are low-density and easily floatable. Camphor was changed to pores in the tablet during the sublimation process. Floating properties of tablets and tablet density were affected by the sublimation of camphor. Release profiles of the drug from the gastro retentive tablets were affected by tablet density/porosity. The effects of different formulation variables HPMC and the effects of different concentrations were studied. The in vitro evaluation was carried out and it was found that the drug release was affected by different concentrations of polymers used. The highest percentage of drug release (96.89±0.83) was observed with xanthan polymer and followed diffusion with erosion mechanism (Non-Fickian transport).