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American Journal of PharmTech Research

📢 Latest Update: New special issue call for papers on "Emerging Technologies in Research" - Submit by March 31, 2025

📢 Latest Update: New special issue call for papers on "Emerging Technologies in Research" - Submit by March 31, 2025

August 2020 Issue 4

Volume 10, Issue 4 - $2020

Volume 10 Issue 4 Cover

Issue Details:

Volume 10 Issue 4
Published:Invalid Date

Editorial: August 2020 Issue 4

Welcome to the 2020 issue of American Journal of PharmTech Research. This issue showcases the remarkable breadth and depth of contemporary research across multiple disciplines. From cutting-edge applications of machine learning in climate science to the revolutionary potential of quantum computing in drug discovery, our featured articles demonstrate the power of interdisciplinary collaboration in addressing global challenges.

We are particularly excited to present research that bridges traditional academic boundaries, reflecting our journal's commitment to fostering innovation through cross-disciplinary dialogue. The integration of artificial intelligence with environmental science, the application of blockchain technology to supply chain management, and the convergence of urban planning with smart city technologies exemplify the transformative potential of collaborative research.

As we continue to navigate an era of rapid technological advancement and global challenges, the research presented in this issue offers both insights and solutions that will shape our future. We thank our authors, reviewers, and editorial board members for their continued dedication to advancing knowledge and promoting scientific excellence.

Dr Hemangi J Patel
Editor-in-Chief
American Journal of PharmTech Research

Articles in This Issue

Showing 24 of 24 articles
Research PaperID: AJPTR104001

Gestational Diabetes Mellitus and Its Association With Pregnancy Outcomes

Vineela Nekkanti, Githa Kishore, Gopavaram Laalasa

Gestational Diabetes Mellitus (GDM) is a common complication of pregnancy resulting from altered glucose tolerance due to β-cell dysfunction and may lead to adverse maternal and perinatal outcomes. This study was aimed at counselling pregnant women with GDM about life-style changes and monitoring their feto-maternal outcomes. This was a prospective observational study carried out in the Obstetrics and Gynaecology department of a tertiary care hospital in Bengaluru. A total of 41 pregnant women attending the study site for antenatal care and had developed GDM from their first trimester were included in the study. Of all the subjects, 63.41% belonged to 26-35 years; 63.41% of pregnant women had parity in the range of 2-5 and 92.68% belonged to the middle and upper socio-economic class of Kuppuswamy scale. About 35 (85.36%) subjects had a new onset of GDM. While the treatment for GDM mainly included oral metformin alone as therapy (26, 63.41%). Lower segment caesarean section (LSCS), preterm births, low birth weight (LBW) and NICU admission were the adverse perinatal outcomes observed. The study concluded that socio-economic status of pregnant women may be a risk factor for GDM and that health education regarding life-style changes (diet and physical activity) for the pregnant women may aid in attaining improved pregnancy outcomes.

GDMPerinatal outcomesAntenatal carePregnancy
317,124 views
95,150 downloads

Contributors:

 Vineela Nekkanti
,
 Githa Kishore
,
 Gopavaram Laalasa
Research PaperID: AJPTR104002

Design and Characterization of Fast Dissolving Buccal Films of Paroxetin

Arjun KL, Ashok Kumar P, Manjunath K, Suresh V. Kulkarni

Depressive Disorder medications are pharmacological agents that are used to treat Major Depressive Disorder disease. The intention of the present study is to design and characterization of fast dissolving buccal films of Paroxetin.  Films were prepared by using different polymers like HPMC E15, PVA, PVP and Glycerol as plasticizer and saccharin as a sweetening agent and vanillin as a flavoring agent. Buccal films were prepared using solvent casting technique. The major problem with Paroxetine was it belongs to class ? in BCS classification and have low solubility in biological fluids. In order to enhance the solubility of Paroxetine solid dispersion of Paroxetine   were prepared by melting technique at different drug carrier (PEG 4000) weight ratios and evaluated. No interaction was found between the drug and the polymers which was obtained by FTIR studies. The buccal films were evaluated for Folding endurance, weight variation, Drug content, Thickness, permeation study and in-vitro drug release study. Dissolution profile were studied by using USP dissolution apparatus type I, pH 6.8 simulated saliva were used as dissolution media. The influence of variable like polymer type, and their concentration, on Paroxetine release profile was studied. The formulation was optimized on the basis of various evaluation parameters like drug content and In-vitro drug release. Formulation F3 successfully gave the fast release of drug within 12 minutes. Stability studies were as per ICH guide lines and result indicated that the selected formulation was stable.

ParoxetineHPMC E15PVAPVPPEG 4000Solvent casting method.
317,256 views
95,100 downloads

Contributors:

 Arjun KL
,
 Ashok Kumar P
,
 Manjunath K
,
 Suresh V. Kulkarni
Research PaperID: AJPTR104003

Peripheral cemento-ossifying fibroma associated with TUBEROUS SCLEROSIS

Pukazhmurasu M, Senthil Kumar S, Krishnan V, Srinivasan S, Kavitha J, Elakiya A

Tuberous sclerosis complex (TSC) was a rare autosomal dominant neurocutaneous disease characterized by benign tumors affecting various body systems, skin changes, neurological disorders, and multi organ development of hamartomas leading to morbidity and death. Intraoral fibromas, gingival hyperplasia and enamel hypoplasia or enamel pits are the most common oral manifestations.Those patient management always involves a multidisciplinary approach from various fields. Here we present a case study of 35 years old female patient with tuberous sclerosis complex characteristic clinical, radiological, and histological features. 

Tuberous sclerosisFibromasHamartoma.
317,024 views
95,136 downloads

Contributors:

 Pukazhmurasu M
,
 Senthil Kumar S
,
 Krishnan V
,
 Srinivasan S
,
 Kavitha J
,
 Elakiya A
Research PaperID: AJPTR104004

Instigation and Characterization of Oral Disintegrating Mini-Tablets Containing Salbutamol Sulphate

Sanjana S, Somashekhar CN

The Main goal of the present study was to develop and evaluate the orally disintegrating mini-tablets (ODMTs) containing Salbutamol sulphate for the treatment of respiratory disorders like Asthma and Chronic obstructive pulmonary diseases. The problems associated with conventional oral dosage forms are associated with slow down onset of action and lag time, while parenterals and aerosol despite of quick-outset of action strongly affect the patient compliance. Quick release tablets are highly accepted rapid increasing drug delivery systems and thus, an attempt was made to improve the onset of action of drug. To reach this goal, selective superdisintegrants like Crospovidone and Sodium starch glycolate were used in different ratios. Micromeritic properties of the powder were within the limit confirmed by free flowing. ODMTs were compressed in order to have sufficient mechanical strength and integrity to withstand handling, shipping and transportation. The tablets were prepared by direct compression method and physicochemical properties were evaluated. FTIR and DSC studies were confirms no chemical interaction between the excipients and drug. Out of six formulations prepared tablet F3 resulted a least dissolution and disintegration time. Hence, concluded that ODMTs give the better effect to the asthma patients and may serve as a successful strategy for enhancing the bioavailability of drug.

Oral disintegrating mini-tabletsSalbutamol sulphateSuperdisintegrantsDirect compression method.
317,415 views
95,303 downloads

Contributors:

 Sanjana S
,
 Somashekhar CN
Research PaperID: AJPTR104005

Saffron (Crocus sativus L.): A Review of its Ethnopharmacological value

Syed Farhan, Shariq Shamsi, Md Tanwir Alam, Aisha Perveen

Saffron (Crocus sativus L.) is widely used as drug to promote health and fight disease from ancient time. In countries like India and other Asian countries, saffron is used very frequently in various alternative systems of medicine including Unani System of Medicine, Ayurveda and Traditional Chinese Medicine, as it is considered  bitter, acrid, fragrant, stimulant, tonic, stomachic, aphrodisiac, anodyne, antispasmodic, emmenagogue, diuretic, laxative, galactogogue and is useful in bronchitis, pharyngopathy, cephalgia, vomiting, fever, melancholia, hepatomegaly etc. Because of its wide range of medical uses in traditional systems of medicine, the saffron has under gone extensive phytochemical and biochemical studies and some of the studies have shown that number of constituents including Crocin, Crocetin, Safranal are present, out of which crocetin is mainly responsible for pharmacological actions. This paper is an attempt to review the saffron on the basis of Unani System of Medicine and to discuss its recent phytochemical and pharmacological studies.

SaffronUnani System of MedicinePhytochemicalsPharmacological actions.
317,544 views
95,321 downloads

Contributors:

 Syed Farhan
,
 Shariq Shamsi
,
 Md Tanwir Alam
,
 Aisha Perveen
Research PaperID: AJPTR104006

Assessment Of Clinical Pharmacy Services Provided by Pharm D Interns In A Tertiary Care Teaching Hospital

Binu Mathew, Jeeva Jose, H. Doddayya

In India the clinical pharmacy services are yet at the infancy stage, very few private hospitals were adopted this system while these services are totally scarce in government hospitals. The aim of the study was to demonstrate the role and importance of clinical pharmacist and to assess the clinical pharmacy services provided. A Prospective analysis of the documented clinical pharmacy services performed by Pharm D interns were assessed for a period of 6 months. A total of 334 past medication history interviews, 333 patient counseling, 325 prescription auditing, 302 drug interactions, 55 medication errors and 23 Drug information queries were provided. Among 272 drug-drug interactions, 60.66% moderate drug-drug interactions and a least of 8.08% major drug-drug interactions and most common management plan recommended was dose adjust­ments (23.52%). Majority of the patients were counseled regarding the name and purpose of the prescribed medicines (96.39 %) and 34.83% reported barriers during their counseling. Among Past medication history interviews, 32.63% of patients had a history of medication intake. 59.38% of prescriptions were not prescribed drugs in their generic names. Maximum number of injections prescribed per prescription was three (20%), antibiotics per prescription were one (44.3%) and 91% of drugs were prescribed from the essential drug list. Of 55 prescribing errors reported majority of errors were belonging to category A (72.72%). It was found that 65.21% queries were to update the requestor’s knowledge and 52.71% used primary sources to respond the queries. The study stresses impeccable role of clinical pharmacist in patient’s care.

PMH interviewspatient counselingprescription auditingdrug interactionsmedication errorsdrug information queries.
317,649 views
95,356 downloads

Contributors:

 Binu Mathew
,
 Jeeva Jose
,
 H. Doddayya
Research PaperID: AJPTR104007

Formulation Development and Evaluation of Herbal Mouthwash

Suchita Gokhale, Raj M Pitambare, Priyam S. Pawar, Ashwini H. Pawshe, Srushti P. Patil

The importance of mouth and teeth cleanliness has been recognized from the earliest days of civilization to the 21st century. Patients and oral health practitioners are faced with a multitude of mouthwash products containing many different active and inactive ingredients. Making informed decisions as to the suitability of a particular product for a particular patient can be a complex task. Although many popular herbal products have helped to control dental plaque and gingivitis, they have been used for a short time and only as an adjunct to other oral hygiene measures such as brushing and flossing. Various herbal products and their extracts such as Turmeric, Triphala, Neem, Tulsi, etc, have shown significant advantages over the chemical ones. Natural mouthwashes may offer significant advantages over the chemical ones. If such mouthwashes can be formulated which can be easily prepared and used safely by people at home using natural products, it may lead to improvement in the general dental health of the population. We have prepared formulation F1 to F5. Then according to antimicrobial activity and evaluation parameters optimized one formulation.

TriphalaTurmericMentholEthanolGlycerin.
317,924 views
95,392 downloads

Contributors:

 Suchita Gokhale
,
 Raj M Pitambare
,
 Priyam S. Pawar
,
 Ashwini H. Pawshe
,
 Srushti P. Patil
Research PaperID: AJPTR104008

Management of COVID-19 Suspected Patients in Critical Care Unit: An Overview Recommendations

Safa Bakr

COVID 2019 is a sever respiratory disease caused by a type of Coronavirus called SARS – CoV-2, a novel coronavirus that has not been previously recorded in human. COVID-19 is is transmitting mainly by respiratory droplet and/or contact, person to person transmission had been pinpointed. COVID–19 may suggest with mild, moderate, or severe illness; the latter includes serious pneumonia. Early recognition of those with serious manifestations grants for urgent advanced supportive care managements and safe, fast entrance (or referral) to intensive care unit according to national obligations. For those with mild disturbance, hospitalization may not be requested unless there is interest for rapid devaluation. All patients pardoned for home should be disciplined to return to hospital if they progress any worsening of illness. We attained good and necessary results for conducting an intubation process for patients who enter intensive care unit in hospitals. We recommend that auxiliary oxygen be given immediately until SpO2 is 100% and presence of viral filtration during intubation technique. The aim of this review was to provide the best practices of intubation and ventilation amid this mass medical emergency and decrease mortality rate.

Intensive care unitCOVID-19IntubationCritical careAnesthesiaRecommendation.
317,957 views
95,394 downloads

Contributors:

 Safa Bakr
Research PaperID: AJPTR104009

Study On Parthenium Hysterphorous for Mosquitoes Larvicidal Potential and The Formulation Of Larvicidal Sachet

Prafull Jundare, Shubhangi Kshirsagar, Aditi Kandalkar, Sunita Jaiswar

In this study crude leaf extract of Parthenium, were tested for their larvicidal activity. The different solvents were used namely ethanol, methanol, water (aqueous) for the preparation of crude extracts from the plant leaves. The larval mortality after 24 hours of exposure were observed separately at concentration like 0.2mg, 0.4mg and 1m extract. The different concentration solvent extract of the plants showed good larvicidal activity. The highest potency was recorded by methanol extract of Parthenium. From These results it was observed that the leaf extract of parthenium contain toxic compounds to mosquito larvae and therefore suggest that parthenium extract has potential in the control of the malaria control and prevention of larvae for social health and can be developed and used.

MosquitoesParthenium hysterophorusbio-pesticidessolventcrude leaf extractconcentration+2 more
318,076 views
95,510 downloads

Contributors:

 Prafull Jundare
,
 Shubhangi Kshirsagar
,
 Aditi Kandalkar
,
 Sunita Jaiswar
Research PaperID: AJPTR104010

Floating Drug Delivery System: A Brief Review

Haridwar Lodh, Sheeba FR, Prabhat Kumar Chourasia, Harshitha Arun Pardhe

Scientific and technological developments in the research and development of new drug delivery systems have been made in recent years by resolving physiological disorders, such as short gastric residence periods and unpredictable gastric emptying times. Dosage forms that can be hold within the stomach are called as Gastro-retentive Dosage Forms (GRDF). Multiple methods used in the prolongation of gastric residence time are floating drug delivery system, swelling and expanding system, polymeric bio-adhesive system, high density system and other delayed gastric emptying system. Medication-based disease treatment is entering a new era in which a increasing range of innovative drug delivery technologies are being used and are available for clinical use. Floating Drug Delivery Systems (FDDS) is one of the gastro-retentive dosage forms used to achieve extended duration of gastric residency. The aim of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with particular focus on the main floating mechanism to achieve gastric retention. Sustained oral release of gastrointestinal dosage types provides many benefits for drugs with absorption from the upper sections of the gastrointestinal tract and those that function locally throughout the stomach. This review includes the physiology, factors controlling gastric retention time, excipient variables influencing gastric retention, approaches to designing single-unit, hydro-dynamically balanced system and multi-unit floating structure, and aspects of their classification, formulation and evaluation are discussed in detail, and few applications of these systems.

Gastro retentive systemFloating drug delivery systemClassificationMethodsEvaluation.
317,995 views
95,502 downloads

Contributors:

 Haridwar Lodh
,
 Sheeba FR
,
 Prabhat Kumar Chourasia
,
 Harshitha Arun Pardhe
Research PaperID: AJPTR104011

A Review on Microspheres: Types, Methods of Preparation, Effects of Process Variables and Applications.

Sunny Patel, Rajeshwar Pandit Kumhal, Pandey Avindra Dinesh, Chetankumar C Gorantli

Microspheres are small particles of spherical form with form below 200 ÎĽm. The analysis is concerned with the microspheres of its benefits, demerits, forms, planning, results and implementation of process variables. Here, in this article it is one of the novel drug delivery system. It overcame a number of problems regarding other forms of dosage. In order to improve bioavailability, the different types of microspheres are used in various ways to provide greater therapeutic efficacy. The effects of process variables on drug trapping, drug release, and particle size are being investigated. Microspheres are typically free flowing powders consisting of naturally biodegradable synthetic polymers. A microsphere has a drug in the middle of the molecule, where it is contained inside a special polymeric membrane.

MicrospheresDrug DeliveryParticle SizeControlled Release.
318,046 views
95,472 downloads

Contributors:

 Sunny Patel
,
 Rajeshwar Pandit Kumhal
,
 Pandey Avindra Dinesh
,
 Chetankumar C Gorantli
Research PaperID: AJPTR104012

Formulation and Evaluation of Lamivudine Floating Tablets by Sublimation Method

M. Sushma, S. Pavani, K.Bharathi

The objective of the study was to develop an oral controlled release drug delivery system of Lamivudine using the sublimation method. Camphor was used as the sublimation material to prepare gastro retentive tablets that are low-density and easily floatable. Camphor was changed to pores in the tablet during the sublimation process. Floating properties of tablets and tablet density were affected by the sublimation of camphor. Release profiles of the drug from the gastro retentive tablets were affected by tablet density/porosity. The effects of different formulation variables HPMC and the effects of different concentrations were studied. The in vitro evaluation was carried out and it was found that the drug release was affected by different concentrations of polymers used. The highest percentage of drug release (96.89±0.83) was observed with xanthan polymer and followed diffusion with erosion mechanism (Non-Fickian transport).

LamivudinefloatingHPMC K4MXanthanCamphorNon-Fickian transport.
318,244 views
95,618 downloads

Contributors:

 M. Sushma
,
 S. Pavani
,
 K.Bharathi
Research PaperID: AJPTR104013

Prolonged Nutmeg Extract Usage As Potent As Glibenclamide In Diabetes Treatment

Jimmy EO, Effiong IE

Comparative antidiabetic potentials study of the effect of ethanolic and aqueous extract of readymade nutmeg with glibenclamide was carried out on thirty (30) male and female albino rats and thirty (30) male and female albino mice for the period of 7, 14, 21 and 35 days. The animals were given low, medium and high doses of extract and 5mg/kg per body weight of glibenclamide for the period. The group administered with high dose of extract of nutmeg had significant  reduction in blood glucose level than (p<0.05), control. The aqueous extract of nutmeg showed significant reduction in blood glucose level on the days with low dose (p<0.05)  compared to control. A combination of nutmeg extract and glibenclamide showed a drastic significant (p<0.05) reduction in blood glucose level. The LD50 of the extract was 2738.1 mg/kg. The phytochemical analysis of the extract showed the presence of alkaloids, flavonoid, tannins, cardiac glycosides and saponins. But flavonoid concentration was very significant. It is showed in the study that prolong usage of aqueous extract of readymade nutmeg is very potent as glibenclamide in the treatment of diabetes. However, ethanolic extract of nutmeg showed higher potency than aqueous extract in the study. Key words: Ethanolic, aqueous, extract, nutmeg, glibenclamide, diabetes.

Ethanolicaqueousextractnutmegglibenclamidediabetes.
318,471 views
95,585 downloads

Contributors:

 Jimmy EO
,
 Effiong IE
Research PaperID: AJPTR104014

Optimization of Parameters for the Production of Protease using Aspergillus Flavus by Solid State Fermentation

Praveen Kumar Dasari

The present work deals with the optimization and production Protease by Artocarpus heterophyllus as substrate in a solid state fermentation using microorganism Aspergillus flavus. Proteases are large and complex group of enzymes that plays a vital role in nutritional and regulatory activities. Proteases are essential for physiological functions in living organisms; they help in breakdown of protein food materials into amino acids, which the body can use for energy, and also play a vital role in essential processes, such as blood clotting, cell division. Solid-state fermentation is defined as a process that occurs on a non-soluble material that acts both as support and a source of nutrients, with a reduced among of water, under the action of fermenting agent. Protease enzyme production conditions like incubation time, incubation temperature, pH, inoculum level and moisture content were optimized. The fermentation time of 72hrs and the temperature of 380C, pH 5, inoculum level of 20%v/w and moisture content of 70%v/w were observed optimum for the production of Protease. Different carbon sources were screened for their influence on enzyme yield; they are glucose, sucrose, fructose and lactose used as supplements. Among these supplements sucrose gave better yield. 0.4% w/w of potassium nitrate as nitrogen source was observed optimum for the production of Protease.

Artocarpus heterophyllusAspergillus flavusSolid-state fermentation.
318,740 views
95,592 downloads

Contributors:

 Praveen Kumar Dasari
Research PaperID: AJPTR104015

Natural Remedies on AIDS: A Review

Pooja Shelar, Khushi Dethe, Kiran Suryavanshi

Acquired Immunodeficiency Syndrome (AIDS) is a clinical infirmity that is a result of infection with Human immunodeficiency virus (HIV), which causes intense immunosuppression. Many compounds of plant origin that inhibit HIV during various stages of cycle theses include several alkaloids, Carbohydrates, Xanthenes and tannins. These compounds have the capability to come up as a medication for therapy of HIV infection. Herbal medication provides rational means for the therapy of Aids, the Herbal drugs which are utilized in Nut, Turmeric, Asoka, Sarpagandha, Cotton Seed, Arjuna. So, the focus of this review article is to pinpoint possessing activity against HIV objective of providing an effective approach for prevention of transmission and therapy of these diseases.

HIVAIDSSyndromeHerbal remedies.
318,688 views
95,599 downloads

Contributors:

 Pooja Shelar
,
 Khushi Dethe
,
 Kiran Suryavanshi
Research PaperID: AJPTR104016

A Validated Stability-Indicating Method for the Estimation of Aceclofenac in Pharmaceutical Dosage Form by RP-HPLC

Sirajunisa Talath, Shaikh Gazi

The aim of the research study was the development and validation of a simple, rapid, accurate and precise reversed-phase high performance liquid chromatography (RP-HPLC) stability-indicating method for the determination of aceclofenac in bulk and pharmaceutical dosage forms. The RP-HPLC studies was performed on the instrument Jasco HPLC system with Jasco UV 2010 photo diode array detector, ODS C18 RP-column (Intersile 250 mm × 4.6 mm; i.d. 10 μm), Rheodyne injection syringe with 20µL loop volume and windows based chrompass software was used for separation. The isocratic elution was performed using the mobile phase ratio of methanol: water (65:35 v/v) and UV detection wavelength at 263 nm. The overall run time of the analysis was 20 minutes and the flow rate was 1.0 mL/min. The RP-HPLC method developed for analysis of aceclofenac was validated as per the ICH guidelines with respect to specificity, selectivity, linearity, accuracy, precision and robustness. The linearity for developed method was observed in the concentration range of 5-50 μg/mL with the correlation coefficient (r2) of 0.9992. The percentage accuracy of aceclofenac ranged from 99.40 to 100.79%. The relative standard deviation for inter-day precision was lower than 2.0%. The assay of aceclofenac was determined in tablet dosage form was found to be within limits. Aceclofenac was subjected to stress conditions such as neutral, acidic, alkaline, oxidation, and photolysis degradations as per ICH guidelines. The results of degradation studies revealed that the drug degraded a maximum (32.68%) in acidic conditions followed by alkaline conditions (15.05%). The drug was found to be resistant towards neutral, acidic and photolytic degradation conditions.

AceclofenacRP-HPLCValidationStability-indicating studiesICH guidelines.
318,955 views
95,737 downloads

Contributors:

 Sirajunisa Talath
,
 Shaikh Gazi
Research PaperID: AJPTR104017

Survival Analysis of SARS-COV-2 in Infected Population of Karnataka State of India

Suhas Bhat, Surekha B. Munoli, Rohan Kolla

Survival probabilities of SARS-COV-2 virus causing COVID-19 in the infectee are tracked using the duration of recovery times of patients in Karnataka state of India. Influence of age, gender, and other symptoms and illness on recovery time is studied. The death of COVID-19 patients and the infectees still under treatment are censored.

SARS-COV-2Survival probabilityKaplan-Meier curveNelson-Aalen CurveMedian time of recovery.
319,077 views
95,669 downloads

Contributors:

 Suhas Bhat
,
 Surekha B. Munoli
,
 Rohan Kolla
Research PaperID: AJPTR104018

Anti-Alzheimer’s disease activity of methanolic extract of Sesbania Grantiflora Leaf

Chaithanya AV1*, Aiswarya Lakshmi AG1, Anjumol MA. 1 1. P. G. Department of Pharmacology, College of Pharmaceutical Sciences, Government Medical College, Kannur-670503, Kerala, India

Alzheimer’s is a disease of the brain that cause problems with memory, thinking and behavior. It is not a normal part of ageing. Alzheimer’s disease is a degenerative brain disease and is the most common cause of dementia. Recognized factors in Alzheimer’s disease include acetylcholine deficiency, increased free radicals and inflammation of the brain tissue. Drugs designed to slow down the disease progression are available. However these medicines have drawbacks of inducing central and peripheral side effects, insomnia, etc. Thus the demand for the new and safer drugs from natural sources have become important. Sesbania grandiflora is an important plant belonging to family Fabaceae which is commonly known as agathi. The reported uses are Anti- convulsant, anxiolytic, Anti-microbial, anti- diarrhoeal and anti-inflammatory. The main active constituents present are alkaloids, flavonoids, tannins and phenolic compounds. Main objective of this study is to establish the anti – Alzheimer’s disease activity of methanolic extract of leaves of Sesbania grandiflora by using various in vivo and in vitro methods. In vitro determination of Anti-Alzheimer’s Disease activity by the neuroprotective effect determination by MTT assay. Invivo anti – Alzheimer’s activity evaluated by stepdown method. Elevated plus maze model: Albino mice divided in to five groups each of 6 animals as follows. Group I: Normal, Group II: Control, Group III: Standard (Donepezil), Group IV & V: Test (High and low doses). After seven days of drug treatment, animals are allowed to explore the maze for 2 min and transfer latency (TL) is measured on seventh and eighth day.

Sesbania grandifloraactive constituentsin vitro in vivo studies
319,223 views
95,731 downloads

Contributors:

 Chaithanya AV1*, Aiswarya Lakshmi AG1, Anjumol MA. 1 1. P. G. Department of Pharmacology, College of Pharmaceutical Sciences, Government Medical College, Kannur-670503, Kerala, India
Research PaperID: AJPTR104019

Study of Lantana Camara, Parthenium Hysterophorus and Allium Sativum Linn. For Mosquito Larvicidal Potential and the Formulation of Larvicidal Sachet.

Aditi Kandalkar, Shubhangi Kshirsagar, Prafull Jundare, Sunita Jaiswar

Mosquito born diseases are nauseous for human being life and were always a never ending hazard . They have also developed a resistance to this chemical insecticides. Alternatively bio-pesticides are been used. In Indian the Lanata camara , Parthenium hysterophorus are weeds that shows the larvicidal activity along with the Allium sativum linn. The present studies has shown the positive results of larvicidal activity. And the methanol as the choice of extract for the extraction process. Formulation of larvicidal sachets and it’s evaluation were done. Leading to sachets formulation which shown high solubility and stability. With the dose dependent activity and showing the effective measures at low concentrations. Which is economical and ecofriendly less toxic then chemical synthetic pesticides, user - friendly, easy availability. Control and prevention of Mosquito larvaes ,using herbs showing larvicidal activity in sachets formulation.

Medicinal herbslarvacidal activityharmful insecticidesbio-pesticidesenvironmental safe.
319,002 views
95,732 downloads

Contributors:

 Aditi Kandalkar
,
 Shubhangi Kshirsagar
,
 Prafull Jundare
,
 Sunita Jaiswar
Research PaperID: AJPTR104020

CP-MLR/PLS derived QSAR rationales for the GPR119 agonistic activity of the Indole-based derivatives

Parihar Raghuraj, Sharma Brij Kishore

QSAR study has been carried out on the GPR119 agonistic activity of indole-based derivatives in terms of Dragon descriptors. The derived QSAR models have revealed that the atomic Sandersons electronegativities weighted and charge accounting descriptors ATS7e, GATS1e, GATS4e and GGI8, molecular mass weighted descriptors, MATS7m and BELm5, and atomic polarizabilities weighted descriptors ATS7p and BELp8, and molecular topology accounting feature Lovasz-Pelikan index (LP1) played a pivotal role in rationalization of GPR119 agonistic activity of titled compounds. Hydrophilic factor (Hy) and certain structural fragments, such as CHR2X (C-008), R--CX--X (C-008) and H attached to heteroatom (H-050) are also predominant to explain GPR119 agonistic actions of indole-based derivatives. PLS analysis has also corroborated the dominance of CP-MLR identified descriptors. Applicability domain analysis revealed that the suggested model matches the high quality parameters with good fitting power and the capability of assessing external data and all of the compounds was within the applicability domain of the proposed model and were evaluated correctly.

QSARGPR119 agonistic activityCombinatorial protocol in multiple linear regression (CP-MLR) analysisPLS analysisDragon descriptorsIndole-based derivatives.
319,140 views
95,833 downloads

Contributors:

 Parihar Raghuraj
,
 Sharma Brij Kishore
Research PaperID: AJPTR104021

Literature Review of Chobchini (Smilax china Linn.)

Tabassum Sultana, Md. Razi Ahmad2 Md Najibur Rahman, Md Tanwir Alam

Plant of Chobchini (Smilax china linn) is commonly occurs in Japan and China, where is it indigenous. In mossy forests at altitudes of 1,600 to 2,400 meters in Bontoc, Lepanto, Benguet, and Zambales Provinces in Luzon, and in Mindanao and Negros. The parts used of this is root, leaves and fruit.  Plant of Chobchini has medicinal value hence used in various diseases and included as an ingredient in a number of formulations. However, its two parts i.e. root and fruit are more commonly used. The plant as whole has described to possess Depurative, demulcent, diaphoretic, stimulant, alterative, antisyphilitic, aphrodisiac. Studies have described Dafe Taffun (antimicrobial), antimutagenic, antioxidant, Muhallil and Dafe Alam (Anti-inflammatory & analgesic), anti-cancer, anti-diabetic and neuroprotective effects. etc. Several studies have been carried out for the therapeutic evaluation of its efficacy and safety. So, I want to compile and summarized all the literature at one space. 

ChobchiniDafe TaffunMuhallil and Dafe Alam.
319,595 views
95,885 downloads

Contributors:

 Tabassum Sultana
,
 Md. Razi Ahmad2 Md Najibur Rahman
,
 Md Tanwir Alam
Research PaperID: AJPTR104022

Therapeutic Indication of Suranjan Shirin (Colchicum luteum)

Wasim Ahmad, Md. Razi Ahmad, Md Najibur Rahman, Md Tanwir Alam

The Colchicum luteum is known by the name of colchicum in English, Suranjan in Sanskrit and Hirantutiya in Hindi. It belongs to the family of Liliaceae. The common names of the plant are autumn crocus and meadow saffron. The corms of the plant are usually used to make natural medicines. It is known to be Phlegm and bile suppressant. These are the principle stabilizing energies that govern the body as well as the mind. It is connected with the structure, lubrication, fluid balance and stability of the entire human body. Test drug Surinjan Shirin is classical and famous Unani drug being used extensively for gouty arthritis in almost every Unani set up. Their said actions are mentioned in various ancient Unani text and some scientific literatures also claim that it has Mulattif (demulcent), Muhallil (Anti-inflammatory) Muarriq (diaphoretic), Muharik (stimulant) etc. activity, and reduces the viscosity of all humours. Hippocrates has described that it maintains the viscosity of all humors. Several studies have been carried out for the therapeutic evaluation of its efficacy and safety. So, I want to compile and summarized all the literature at one space. 

ColchicumChobchiniMulatifMuhalli-e-waramMuarriqMuharik.
319,369 views
95,960 downloads

Contributors:

 Wasim Ahmad
,
 Md. Razi Ahmad
,
 Md Najibur Rahman
,
 Md Tanwir Alam
Research PaperID: AJPTR104023

A Literature Review of Luk Maghsool (Lac)

Seraj Ahmad, Md. Razi Ahmad2 Md Najibur Rahman, Md Tanwir Alam

Luk Maghsool (Lac) is the resinous secretion of a number of species of lac insects, of which the most commonly cultivated is Kerria lacca. Cultivation begins when a farmer gets a stick that contains eggs ready to hatch and ties it to the tree to be infested.1 Thousands of lac insects colonize the branches of the host trees and secrete the resinous pigment. The coated branches of the host trees are cut and harvested as sticklac. The harvested sticklac is crushed and sieved to remove impurities. The sieved material is then repeatedly washed to remove insect parts and other material. The resulting product is known as seedlac. The prefix seed refers to its pellet shape. Seedlac, which still contains 3–5% impurity, is processed into shellac by heat treatment or solvent extraction. The use of lac since ancient times in different alternative system of medicine like Unani, Ayurveda etc. for the treatment of Obesity (Saman-e-Mufrat), Dyslipidaemia (Fart-e-Tadassum-Fid-Dum), Liver disease (Amraz-e-Jigar), Anti-helminthic (Deedan-e-meda wa ama) etc. Several studies have been carried out for the therapeutic evaluation of its efficacy and safety. So, I want to compile and summarized all the literature at one space. 

uk MughsoolSaman-e-MufratFart-e-Tadassum-Fid-DumAmraz-e-JigarDeedan-e-medad wa amma
319,590 views
96,016 downloads

Contributors:

 Seraj Ahmad
,
 Md. Razi Ahmad2 Md Najibur Rahman
,
 Md Tanwir Alam
Research PaperID: AJPTR104024

Clinical Correlation of Taqashshur-E-Jild with Psoriasis: A Literary Approach

Saziya Sohel, Md. Razi Ahmad, Md Najibur Rahman, Md Tanwir Alam

Psoriasis is one of the most common dermatologic diseases. It is a chronic non-infectious inflammatory disease of the skin, characterized by development of chronic, well defined, scaly, erythematous, plaques on the extensor aspects of the body, especially on the elbows, knees, trunk, back and scalp1,2,3,4. Nail involvement is very frequent and often gives the clues to the diagnosis1,2,3,4,5,6. Psoriasis can be localized or generalized. High variability and unpredictability are the hallmark of this chronic affliction. The estimated prevalence is 1.5% to 3% in general population. It has bimodal peak of incidence, at 16-22 years and 57-60 years. In Unani System of Medicines, Galen was the first person who described a skin disease in the name of psoriasis7,8. But before and after the Galen many Unani physicians described the various names such as Sadafia, daus sadaf, baheq-e- siyah and Samakia9. In classics of Unani literature various references are found such as Sadafia, Da-us- Sadaf, Baheqe siyah, Samkia and qubae mutaqashshar which qualify for the disease of psoriasis1,10. Celsus described impetigines and specified that the second species of impetigo was characterized by red skin covered with scales. This description suggested a type of papulosquamous disease, such as psoriasis. So, keeping the fact in mind want to established the clinical correlation with anaemia in the light of classical Unani literature as well as modern medicine.

Taqashshur-E-Jildbaheq-e- siyah and SamakiaSadafiaDa-us- SadafBaheqe siyahSamkia and qubae mutaqashshar.
319,810 views
96,055 downloads

Contributors:

 Saziya Sohel
,
 Md. Razi Ahmad
,
 Md Najibur Rahman
,
 Md Tanwir Alam
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