Buccal drug delivery system

Current innovation in pharmaceuticals determine the merits of mucoadhesive drug delivery system is particularly relevant than oral control release, for getting local systematic drugs distribution in GIT for a prolong period of time at a predetermined rate. The demerits relative with the oral drug delivery system is the extensive presystemic metabolism, degrade in acidic medium as a result insufficient absorption of the drugs. However parental drug delivery system may beat the downside related with oral drug delivery system but parental drug delivery system has significant expense, least patient compliance and supervision is required. By the buccal drug delivery system the medication are directly pass via into systemic circulation, easy administration without pain, brief enzymatic activity, less hepatic metabolism and excessive bioavailability. This review article is an outline of buccal dosage form, mechanism of mucoadhesion, in-vitro and in-vivo mucoadhesion testing technique.

The aim of the present study was to prepare buccoadhesive sustained release tablets of sumatriptan succinate using novel permeation enhancer to release the drug for extended period of time with reduction in dosing frequency. In the present work sumatriptan succinate was used as a model drug and interaction studies performed using FTIR spectroscopy and DSC revealed that there was no drug, polymer and permeation enhancer interaction. Fulvic acid was extracted from shilajit by using resins. Fulvic acid was characterized by various spectroscopic techniques. Buccoadhesive sustained release tablets of sumatriptan succinate with novel permeation enhancer were prepared by direct compression method using bioadhesive polymers like carbopol 934 and HPMC. The physical characteristics like surface pH, swelling index, in vitro mucoadhesion strength, in vitro drug release and in vitro permeation of formulated tablets were shown to be dependent on characteristics and composition of bioadhesive materials used. The in vitro release study showed 99.88% of drug release with fulvic acid, respectively. Fulvic acid containing tablet has shown enhancement in permeation of drug of 93 % in 12 hours across buccal mucosa in comparison with plain sumatriptan succinate tablet. Sumatriptan succinate release from the buccoadhesive system was extended and exhibited a non fickian drug release kinetics approaching to first order as the values of release rate exponent varied between 0.97 to 0.99 resulting in a regulated and complete release until 8 hours.

The aim of the present study was to prepare buccoadhesive sustained release tablets of sumatriptan succinate using various permeation enhancers to release the drug for extended period of time with reduction in dosing frequency. In the present work sumatriptan succinate was used as a model drug and interaction studies performed using FTIR spectroscopy and DSC revealed that there was no drug, polymer and permeation enhancer interaction. Fulvic acid was extracted from shilajit by using resins. Fulvic acid was characterized by various spectroscopic techniques. Buccoadhesive sustained release tablets of sumatriptan succinate with various permeation enhancers were prepared by direct compression method using bioadhesive polymers like Carbopol 934 and HPMC K100M. The physical characteristics like surface pH, swelling index, in vitro mucoadhesion time, in vitro mucoadhesion strength, in vitro drug release study and in vitro permeation study. The in vitro release study showed 99.88%, 99% and 99.40% of drug release with fulvic acid, chitosan and beta cyclodextrin respectively. The permeation study showed 90%, 82% and 78% of drug permeated with fulvic acid, chitosan and beta cyclodextrin respectively. Sumatriptan succinate release from the buccoadhesive system was extended and exhibited a non fickian drug release kinetics approaching to first order as the values of release rate exponent varied between 0. 97 to 0.99 resulting in a regulated and complete release until 8 hours.

Lignocaine Hydrochloride (LH) is a local anesthetic agent used in the treatment of periodontal and various other dental diseases. It undergoes extensive first pass metabolism with a consequent low bioavailability. Keeping this into account the research work was focused to formulate buccal tablets of LH in an effort to achieve prolonged relief from pain. Buccal tablets were prepared by direct compression method using different bio-adhesive polymers such as chitosan with methocel K15, sodium alginate and methocel K4. Ethyl cellulose (EC) was used as an impermeable backing layer. The optimized formula (F9) was evaluated for in vitro drug release (99.51%±0.59) in phosphate buffer for 6 hrs and bio adhesion strength was found to be 22 gr. The amount of drug permeated through the buccal membrane was found to be 85.03 ±0.21.Stability studies of the F9 indicated no significant changes with respect to drug content, in-vitro release and ex-vivo permeation. Key Words: Lignocaine hydrochloride, Buccal drug delivery system, First pass hepatic metabolism, Ex vivo permeation studies.