Bioavailability enhancement.

Throughout the last 20 years, several trendy technologies are established within the pharmaceutical analysis and development space. The automation of the drug drug discovery method by technologies like high output screening, combinatorial chemistry and computer aided drug design is resulting in a huge range of drug candidates possessing a very good efficacy. Unfortunately, several of drug candidates are a unit exhibiting poor liquid solubility. The use of drug nanocrystal is an universal formulation approach to extend the therapeutic performance of those medication in any route of administration. Drug nanocrystals are crystals with a size range in the nanometer range, meaning that they are nanoparticles with a crystalline character. This review describes the chemistry properties of drug nanocrystals, production method and potential clinical advantages. Poorly soluble medication are usually difficult drawback in drug formulation. Reducing the particle size of a drug to a nono-scale leads to an increased in surface area-to-volume ratio, increased dissolution velocity and improved in vivo performance of poorly soluble drugs.