Analgesic

Inflammation is a complex biological response of vascular tissues to harmful stimuli. The stimulus may be thermal (heat or cold), chemical (foreign substances, foreign organisms, drugs), or mechanical (trauma). Anti-inflammatory agents are the agents which relieves the inflammation. Amino acids L-tyrosine was refluxed in presence of thionyl chloride and methanol for 8 hrs to form its methyl ester hydrochloride(a). Compound (a) and taurine were refluxed with Salicylic acid in 30 % NaOH solution for 2 hrs and neutralized with conc. hydrochloric acid to precipitate target compounds (b, c). These compounds were characterized on basis of melting point, TLC (Rf value), IR and 1H NMR spectra and evaluated for analgesic and anti-inflammatory activity. Target compound (b) was found to be most active with 96.3 % protection for analgesic and anti-inflammatory activity.

  Jasminum sambac (L.) Aiton (Oleaceae) is traditionally used as an antinociceptive and anti-inflammatory agent. The objective of this study was to investigate experimentally the possible analgesic and anti-inflammatory properties of Jasminum sambac. The effect of petroleum ether extract of leaves of Jasminum sambac (PEJS) was evaluated in experimental models of pain and inflammation. The leaf extract at 200 and 400 mg/kg showed significant decrease in acetic acid induced writhings in mice with a maximum of 67.49 % at 400 mg/kg. In tail immersion and hot plate method, treatment with PEJS (200 and 400 mg/kg) showed significant (p