Aegle marmelos

This article provides a review on the pharmacological effects of Aegle marmelos. It is belonging to Rutaceae family. The Aegle marmelos is also known as Bael, Bilwa and wooden apple plant. It contains various bioactive components in leaves, flowers, fruits, wood, root, and bark which has different biological activities and high therapeutic importance. The phytochemical compounds which are isolated from the Aegle marmelos are Coumarins (Marmelosin, marmesin, imperatorin), alkaloids (Aeglin, aegelenine), Tannins (skimmianine), Carotenoids and seed oils and other miscellaneous compounds. The phytochemical components of this plant showed various pharmacological and biological activity against certain chronic diseases like cancer, cardiovascular disease, immunosuppressive disease and gastrointestinal disorder. The different parts of this plant extract possess pharmacological activities like anticonvulsant, antioxidant, anti-inflammatory, antidiabetic, antidiarrheal, antihyperglycemic, anxiolytic, antidepressant, antihistaminic, antimicrobial, hepato protective, analgesic, immuno modulatory, cardio protective and antithyroid activities. The present review summarizes the information about botany, ethnopharmacology, phytochemistry, biological activities and insecticidal properties of A. marmelos plant.

In present investigation, methanolic extract of different marketed Aegle marmelos formulations (F1, F2, F3, and F4) screened for determination of total phenolic and flavanoid contents.  Highest phenolic (6.145 ± 0.05 mg/kg) and flavonoid (8.134 ± 0.044 mg/kg) contents were noticed in formulation F4. Free radical scavenging activity of all the studied formulations were evaluated by using DPPH (1,1-Diphenyl-2-picryl hydrazyl) method. Whereas, each formulation showed good scavenging of DPPH radical with IC50 values (F1-2.185, F2-2.216, F3-2.243 and F4-2.143 µg/ml), and is comparable to standard compounds (BHT, ascorbic acid and rutin). Key-Words: Aegle marmelos, Total phenolic contents, Total flavanoid contents, DPPH  

In the present investigations, methanolic extracts of four marketed Aegle marmelos formulations (F1, F2, F3, and F4) were prepared and subjected to simultaneous quantitative determination of two biologically active compounds; umbelliferone and quercetin. Analysis of umbelliferone and quercetin was performed on TLC aluminum plates pre-coated with silica gel 60F-254 as stationary phase. Linear ascending development was carried out in twin trough glass chamber saturated with mobile phase consisting of toluene: ethyl acetate: formic acid (6:4:1, v/v/v), and densitometric determination of these compounds was carried out at 300nm in reflectance/absorbance mode. The system was found to give compact spots for umbelliferone and quercetin with Rf value of 0.66 and 0.68, respectively. The present method was validated for precision, recovery, repeatability, and accuracy in accordance with International Conference on Harmonisation (ICH Q2) guidelines. Statistical analysis of the data showed that the method is reproducible and selective for estimation of umbelliferone and quercetin. This method may be used for routine quality control and standardization of the herbal drugs and there formulations. Key words: Aegle marmelos, Quercetin, Umbelliferone, HPTLC