Acetic acid

Ring acylations of aromatic substances are very difficult to achieve to a great extent. Nencki reaction has attempted on mono to poly hydroxy and substituted phenols have good results. Reactions are using solely acetic acid, acetic anhydride and adipic acid or mixture of acid and anhydride resulting complete consumption of phenols. The use Lewis acid freshly fused ZnCl2 is best suitable catalyst compare to others. The essential data on phenols acylation has been studied and described as below. 

A simple, rapid and accurate high performance liquid chromatography method is described for determination of rupatadine fumarate from its active pharmaceutical ingredients. The separation of drug was achieved on Inertsil ODS-3 C18 (250 X 4.6 mm) 5µ column. The mobile phase was a mixture of acetonitrile and methanol (80:20 v/v) : buffer of pH  4.5 [70:30 % v/v]. The buffer of pH 4.5 was prepared from 0.01 M ammonium acetate and pH was adjusted with dilute acetic acid. The detection was carried out at wavelength 250 nm. The mixture of water: acetonitrile (30:70 % v/v) was used as a diluent. The method was validated for system suitability, linearity, accuracy, precision, robustness, stability of sample solution. The method has been successfully used to analyze rupatadine fumarate from pharmaceutical formulation.