Utkarsh Singh

The aim of present study was to design and development of a proniosomal transdermal drug delivery system of lornoxicam for the treatment of rheumatoid arthritis and enhanced skin targeting effect, sustained & prolonged drug release, enhanced skin bioavailability by using different type of non ionic surfactant & cholesterol. Proniosomes of Lornoxicam were prepared by coacervation-phase separation method. The formulation systems were characterized in vitro for size, vesicle count, drug entrapment, drug release profile and vesicular stability. The method used for preparing proniosome resulted in an encapsulation yield of 67.71-87.64%. Proniosomes were characterized by transmission electron microscopy. In vitro studies showed prolonged release of entrapped lornoxicam. A successful attempt was made to develop proniosomal gel for transdermal delivery of lornoxicam using different grades of nonionic surfactant.

Oral drug delivery has been known for decades as the most widely utilized route of administration among all the routes. United State Food and Drug Administration (FDA) defined ODT as “a solid dosage form containing medicinal substance or active ingredients which disintegrate rapidly usually within a matter of second when placed upon the tongue. Propranolol is a nonselective beta-adrenergic blocker and is almost completely absorbed following oral administration. However , most of drug is undergoes high first-pass metabolism by the liver and on average, only about 25% of propranolol reaches the systemic circulation. The present study investigated to development of novel fast dissolving tablet of Propranolol HCL which was by first pass metabolism, provide rapid onset of action and increasing the bioavailability of the drug. The fast dissolving tablets were prepared by Direct compression method by using different superdisintegrant like Crosspovidone, crosscarmellose sodium, sodium starch glycolate etc. The advantage of this formulation is such that in case of hypertension attack patient can take the drug without the usage of water. Therefore the main objective of the present work is to develop orodispersible tablets of Propranolol hydrochloride to improve bioavailability, disintegration time, dissolution efficacy and patient compliance.

Fast dissolving Tablets are disintegrating and/or dissolve rapidly in the saliva without the need for water. Some tablets are designed to dissolve in saliva remarkably fast, within a few seconds, and are true fast-dissolving tablets. Others contain agents to enhance the rate of tablet disintegration in the oral cavity, and are more appropriately termed fast-disintegrating tablets, as they may take up to a minute to completely disintegrate. Oral delivery is currently the gold standard in the pharmaceutical industry where it is regarded as the safest, most convenient and most economical method of drug delivery having the highest patient compliance. By the addition of piperine in the fast dissolving formulation, its bioavailability increases, hence dosing reduces.