Ugandar R E

The present study was aimed to evaluate the wound healing activity of extract of seeds of Swietenia macrophylla. It is well-known plant in Asian traditional medicines. On the basis of traditional use and literature references, this plant was selected for wound healing potential. The ethanolic extract of seeds of Swietenia macrophylla was examined for wound healing activity in the form of ointment in the excision wound model using Albino rats. The extract ointments showed efficient response in the excision wound model as comparable to the group treated with standard drug Betadine ointment and control group in terms of wound contracting ability, wound closure time and epitheliallization period. Histological analysis was also consistent with the proposal that Swietenia macrophylla seed extract exhibits significant wound healing. Swietenia macrophyllan was found to possess significant wound healing property. This was evident by decrease in wound closure (P

The research involve formulation and evaluation of three different ophthalmic solutions of Ketorolac tromethamine with three different amino acid transporters. The prepared formulations were subjected to ex-vivo transcorneal permeation and cornea hydration studies through excised goat cornea and the results were compared with those of a prepared standard Ketorolac tromethamine ophthalmic solution. The trans corneal permeation studies were carried out by using an all glass Franz diffusion cell. The non-steroidal anti-inflammatory drug Ketorolac tromethamine ophthalmic solution is indicated for the temporary relief of ocular itching due to seasonal allergic conjunctivitis and also for the treatment of inflammation following cataract surgery. In the study, the three amino acid transporters used were Lysine, Phenylalanine and Valine which are responsible for protein synthesis and play a significant role in the process of maintaining structural and functional integrity of conjunctiva and retina. The results obtained from the permeation studies of conjugated physical mixtures of Ketorolac tromethamine with different amino acid transporters across the excised goat cornea were observed to exhibit enhanced permeation when compared with the permeation of Ketorolac tromethamine from the standard formulation.

Trees and shrubs products have been used as principal ingredients that aid human health and well-being. Based on the literature review and traditional uses of plant Annonasquamosa (Family; Annonaceae), the present study was aimed to evaluate the CNS depressant activity of ethanol, petroleum ether and aqueous extracts of the leaves of AnnonaSquamosa in albino mice. The rotarod test and diazepam induced sleep test was used to evaluate the activity of extracts interfering with motor co-ordination and sleeping time at a dose of 200 mg/kg. 30 minutes after i.p. administration of extracts. The difference in the fall off time from the rotating rod and onset and duration of sleeping time between the control and the treated mice was recorded. It can be inferred from the results that the A. squamosaleaves extracts were exhibiting interesting aimed activity against the control group, however not on par with that of standard employed. Based on the results we can conclude that the ethanol crude extract of A. squamosaleaves exhibit significant CNS depressant activity.