Tripura Sundari

Oral analgesics are commonly prescribed  for the treatment of acute and chronic pain, but these  agents often produce adverse systemic effects, which some times are severe ,so topical administration of analgesics is an alternative method. The  aim of  present work is to develop semi solid preparations of natural analgesics like camphor. Three different strengths were prepared which are 25mg,50mg,100mg in two different bases that are hydrophilic and hydrophobic. All the prepared  formulations  were evaluated  for PH, spreadability, diffusion studies. The selected formulations were evaluated for in-vivo studies in comparison with marketed preparations .The  finalized preparation was kept for stability studies according to ICH guidelines. Keywords: Pain, Camphor, Ointment.

BioMEM’s are the biologically oriented MicroElectro Mechanical systems which are currently giving good market in the medical field and also attracting many researches for its development. These devices are defined as “devices or systems, constructed using techniques inspired from micro scale and nanoscale fabrication that are mainly for processing, delivery, analysis of biological and chemical entities. These BioMEM’s are having advantages over disadvantages. BioMEM’s are capable of analyzing biochemical liquid sample like solution of metabolites, macromolecules, proteins, nucleic acid cells and viruses. And there is currently  a large amount of BioMems work in the arena of drug delivery systems using micro fabrication technique. BioMems are under research in the field of drug delivery which helps in the future for the many dreadful diseases.  This review mainly gives an information about the different applications of BioMEM’s in the medical field.

Nanoparticles are submicron nano sized particles having the size range of about 1-100nm range. Because of their sub-microscopic size, they have unique material characteristics, and manufactured nanoparticles may find practical applications in a variety of areas, including medicine, engineering, catalysis, and environmental remediation. Escitalopram (ETP), an SSRI (selective serotonin reuptake inhibitor), and s-enantiomer of citalopram is exclusively used as an antidepressant. The drug shows extensive hepatic metabolism, reduced drug efficacy and potential side effects, which reduces its therapeutic index. So, the present study is focused on increasing the solubility and thus the bioavailability. The nanoparticles were prepared by using hot homogenization method by using Cutina as lipid, soya lecithin as lipophilic surfactant and PEG as hydrophilic surfactant. The prepared solid lipid Nanoparticles were evaluated for Drug content, entrapment efficiency and dissolution studies and stability studies and found that the Drug content ( 90.7%), Entrapment efficiency (  86.1 %) and Drug release of  ( 82.4%), Particle size( 796nm) and Zeta potential ( -29.4mV)

The solubility and bioavailability of a drug is very important while preparing a formulation.BCS class-II drugs like clopidogrel have the problem of poor bioavailability because of less solubility. So many novel techniques were available to improve the solubility aspects of drug among which solid lipid nanoparticles is a promising approach. In the current study attempts were made to formulate and evaluate clopidogrel loaded solid lipid nanoparticles by employing cutina as lipid and lecithin soya and PEG-400 and TWEEN-80 were used as surfactant systems. Different formulations were prepared and analyzed for drug content, entrapment efficiency, drug release studies. The selected formulations were analyzed with stability studies at two different conditions which is, room temperature and refrigerated conditions.

Drug delivery via nanoparticle-based carriers has shown promising results for different types of diseases. Delivery of anti-gout agents into body is a mature line of investigation that has yet to realize its full potential. In this study we report on the development of a delivery platform for febuxostat. The work presented here describes the development of nanoparticles based on compritol. The method employed for the preparation of SLN is micro emulsification technique followed by high pressure homogenization. Phase diagram was developed to know the region of stable micro emulsion formation. Eight different formulas were developed with different concentrations of lipid, surfactant and aqueous concentrations. The developed formulations were evaluated for particle size distribution, zeta potential, entrapment efficiency, DSC thermal analysis and in vitro drug release studies. Among all the formulations developed, F3 formulation is showing better drug entrapment efficiency and controlled release of drug up to 24h. There was 12 fold increase in the solubility of drug in the developed formulation. The solid lipid nanoparticles of febuxostat can be prepared by using simple micro emulsification technique. The formulations had shown better release profile and solubility characteristics.