Tara Chand

The objective of this present study is to formulate and evaluate the floating drug delivery system of Bambuterol HCl prepared by using synthetic polymers. Formulations were prepared by direct compression technique and sodium bicarbonate was incorporated as gas generating agent. Using different polymers of hydroxyl propyl methylcellulose (HPMC) such as, HPMC K100M, HPMC K4M and HPMC K100M for their gel-forming properties. The compressed Bambuterol HCl floating tablets were evaluated for physical parameters like Tablet Thickness, Hardness, % Friability, Weight variation, Content uniformity, In vitro buoyancy, Swelling index and In vitro dissolution study. Its bioavailability was reported about 20%. As the concentration of the polymers in the formulations increased the drug release decreased. Hence it was considered suitable candidate for formulation as gastro-retentive floating drug delivery system. Floating tablets has been accepted as a process to achieve controlled drug delivery by prolonging the residence time of the dosage form at the site of absorption, thereby improving and enhancing the bioavailability of drug.

In the present research paper, Sodium valproate tablets were prepared by using Syloid FP244 polymer. The tablets were formulated by using wet granulation techniques. Further post formulation parameters like hardness, friability, weight variations and content uniformity were studied. The results suggested, that the prepared enteric coated tablets specifics all the criteria of the standard formulation as per specified in monographs. 

Salvadora persica L. (family- Salvadoraceae) is an evergreen small tree commonly known as Pilu, Jal and toothbrush tree. It is used in the treatment of pain, low fever, toothache, nose trouble, piles, scabies, inflammation, scurvy, gonorrhoea, chest disease and boils.  The present study was undertaken to evaluate the antinociceptive activity of the successive extracts (chloroform, ethyl acetate, ethanol and aqueous extracts) of powdered leaves of Salvadora persica L. at the dose of 500 mg/kg b. w. using eddy’s hot plate method. The results of the statistical analysis showed that chloroform and ethyl acetate extracts have significant antinociceptive activity. From the results of antinociceptive effects it can be concluded that the chloroform extract of the powdered leaves of Salvadora persica has shown significant activity (P < 0.05) at 30 min and significant activity (P < 0.01) at 60 and 120 minutes. The ethyl acetate extract has shown significant activity (P < 0.01) at 30, 60 and 120 minutes when compared to the control group. While the standard drug (Morphine Sulphate) shown significant activity (P < 0.01) at 30, 60, 120 and 180 minutes. Other successive extracts (ethanol and aqueous extracts) could not produce the significance of the difference from the control as antinociceptives. Hence present investigation reveals the antinociceptive activity of chloroform and ethyl acetate extracts of leaves of Salvadora persica L Key Words: Salvadora persica L. antinociceptive activity, chloroform and ethyl acetate extracts

The aim of present study was to estimate the in vitro antioxidant activity of alcoholic extract of Cucumis callosus (Rottl.) Cogn (Cucurbitaceae) seeds which is commonly known as “Kachri” in Rajasthan (India) evaluated by using DPPH radical scavenging activity and hydrogen peroxide radical scavenging activity assay. The antioxidant activity was compared with ascorbic acid as standard. The IC50 values of Cucumis callosus and ascorbic acid were found 41.99 μg/ml and 24.27 μg/ml respectively for the DPPH radical scavenging activity while 95.27 μg/ml and 153.35 μg/ml respectively for hydrogen peroxide radical scavenging activity. Thus, alcoholic extract of Cucumis callosus seeds possess potent antioxidant activity in hydrogen peroxide model and may be useful for preparation of neutraceuticals as potent antioxidant to treat various human diseases. Key words: Cucumis callosus, Seeds, Antioxidant, Free radical scavenging, DPPH