Taher S. Bohari

Valacyclovir hydrochloride  is widely used for the treatment on Herpes virus, illness caused by Herpes virus such as Genital herpes, Cold sores, Chingles and Chicken pox. The present study is deals with formulation, optimization, evaluation of Valcyclovir HCL mouth dissolving films. Genital herpes, Cold sores, Chingles and Chicken pox are the conditions where instance effect of drug is required. Valacyclovir hydrochloride is one of the drug which is used in the treatment of above three disease conditions. The mouth dissolving films was prepared by using solvent casting method. The concentration of propylene glycol, sodium lauryl sulphate (SLS) were kept constant in all formulations (F1-F4) and varying concentration of hydroxy propyl methyl cellulose(HPMC) and methyl cellulose. All the formulations were evaluated for surface pH, weight uniformity, folding endurance, drug content, disintegration time, in-vitro dissolution studies. The formulation ‘F3’ was found to be optimized formulation. It shows results for all evaluation parameters such as weight variation 34.70±0.7mg, surface pH 6.75±0.60, folding endurance > 100, drug content 95.25±1.10%, disintegration time 30±0.50 sec, and in-vitro dissolution study 81.35±1.30 % at the end of 5 min.