Surendra Kumar Jain

The aim of this investigation was to develop and optimize Metformin HCl matrix tablets for sustained release application by response surface methodology based on two factor-three response factorial design. The effects of the amounts of polysaccharide from tamarind and polysaccharide from jackfruit in Metformin HCl matrix tablets on the properties of Metformin HCl sustained release matrix tablets drug release was analyzed and optimized. The observed responses were coincided well with the predicted values by the experimental design. The optimized Metformin HCl matrix tablets showed prolonged sustained release of Metformin HCl over 6 hours. These matrix tablets followed the first-order model with anomalous (non-Fickian) diffusion mechanism.

A series of novel E-3- (phenyl)-2-(phenyl) prop-2-enoic acid derivatives (1a-1h and 2a-2e) have been synthesized by the base-catalyzed condensation of phenylacetic acids (1) with aryl aldehyde in the presence of triethylamine gave the series of E-3- (phenyl)-2-(phenyl) prop-2-enoic acid (1a-1h). Reaction of thionyl chloride with the E-3- (phenyl)-2-(phenyl) prop-2-enoic acid in benzene under refluxing gave the corresponding acid chlorides, which on subsequent reaction with appropriate amines, and (dialky1amino) ethanol gave compounds 2a-2e the yield of compound was found to be in the range of 60-85%.The synthesized compounds were characterized by their physiochemical properties like solubility, melting point, IR spectroscopy, 1H NMR spectroscopy, Fab MASS and elemental analysis.