Tamarind

Indian borage leaves (Coleus amboinicus) at dose of 620mg/KgBB and tamarind (Tamarindus indica) at dose of 300mg/KgBB effectively decrease glucose contain in blood with work mechanism by reducing oxidative stress in body. Flavonoid contain in these plants was thought to play role as anti-diabetes. Because of the efficacy similarity of these plants, so the combination of Indian borage and tamarind extract was made in liquid herbal dosage form. The liquid herbal in this research were intended to oral use, so they can be given additional flavoring, sweetener, or water- soluble dyes to improve dosage quality. Liquid herbal dosage were made in 4 formulas based on different types of sweeteners, the test result showed that liquid herbal with palm sugar sweetener was the most preferred by panellists. Selected formulas from the test of preference was tested for quality testing include : stabilization test at three different temperatures over a period of 8 weeks with parameters pH measuring, viscosity, specific gravity, organoleptic, determination of flavonoid content and testing of microbial contamination. Stability test result showed a change in the quality and decrease in flavonoid levels in liquid herbals dosage every week. Based on data on the decrease in flavonoid contain in stability test, the prediction of the shelf  life of liquid herbals dosage was obtained for 8 week at room temperature. Keywords: Liquid herbal, Indian borage leaves, Tamarind, Antidiabetes, Stability test

The aim of this investigation was to develop and optimize Metformin HCl matrix tablets for sustained release application by response surface methodology based on two factor-three response factorial design. The effects of the amounts of polysaccharide from tamarind and polysaccharide from jackfruit in Metformin HCl matrix tablets on the properties of Metformin HCl sustained release matrix tablets drug release was analyzed and optimized. The observed responses were coincided well with the predicted values by the experimental design. The optimized Metformin HCl matrix tablets showed prolonged sustained release of Metformin HCl over 6 hours. These matrix tablets followed the first-order model with anomalous (non-Fickian) diffusion mechanism.