Suman Jain

The objective of this paper was to attempt to investigate a review the Development and evaluation of mouth dissolving antinflammatory tablet containing fenoprofen. MDT is used methods to improve patient’s compliance have always attracted scientists towards the development of fancy oral drug delivery systems. Among them, mouth dissolving drug delivery systems (MDDDS) have acquired an important position in the market by overcoming previously encountered administration problems and contributing to extension of patent life. In the present scientific scenario the drug delivery technology has become highly competitive and rapidly evolving with ever increasing demand. Fast dissolving tablet (FDT) is one such type of an innovative and unique drug delivery system which is swiftly gaining much attention in the research field of rapid dissolving technology. Oral route is the most expedient and safest route of drug delivery because of wide range of drugs are administered through this route. Recently researchers have developed fast dissolving tablet (FDT) which dissolve or disintegrate rapidly in mouth saliva without intake of water. This novel drug delivery such as FDT or MDT (mouth dissolving tablet) has overcome many disadvantages like dysphagia or non accessibility of water while travelling. When compared with conventional dosage form FDT can be a useful alternative as well. This review article contains different techniques used for preparing FDT, silent features, various patented technologies, and mechanism of super disintegration, challenges faced and the limitations.

In an endeavor to boost the prophylactic action of Quercetin Dihydrate against mustard agent poisoning, mucoadhesive microspheres, were formulated. The microspheres enclosed Quercetin Dihydrate, an adhesive polymer (ethyl cellulose) and a colon specific polymer (Eutragit S100). Microspheres were devised by an oil/water emulsification solvent evaporation method. Two variables polymer concentration and plasticizer concentration for formulation were used. The mean particle sizes of the prepared microspheres were found significantly increasing with polymer concentration and decreased with increasing plasticizer concentration. The drug entrapment effectiveness increased with increasing plasticizer concentration. The Percentage mucoadhesion increases with increasing concentration of ethyl cellulose but not much affected by concentration of eudragit. Drug entrapment efficiency was found in range of 73.35±2.7 (batch R1) to 80.61±1.54 (batch F5). The entire formulations had excellent flow property. The best fit release kinetic model was found to be Higuchi for all formulations, which indicated release from matrix type formulation. The In vivo studies on male wistar rats were conducted and plasma concentration time method was employed to study the influence of quercetin by formulating it as microspheres. By Statistical Analysis through sigma plot, the semi log plot of pure drug (Quercetin) and its microspheres shows linearity which indicates that they follow linear kinetics. Formulation of microspheres produced a sustained effect on its absorption and availability and several parameters are there which concluded that the microspheres of quercetin are better choice for mustard toxicity as compared to pure drug.