Snehalatha Boddu

A simple and sensitive spectrophotometric method for the determination of albendazole and levamisole hydrochloride in pharmaceutical dosage forms has been developed. The absorption maxima were found at 295nm for albendazole and 213 nm for levamisole hydrochloride using ammonium dihydrogen phosphate: methanol as solvent. Beer's law was obeyed for both the drugs in the concentration range of 5-25 for albendazole with correlation coefficient 0.998 and 2-10 for levamisole hydrochloride with correlation coefficient 0.997. The limits of detection for albendazole and levamisole hydrochloride were found to be 0.305µg/mL and 0.732µg/mL respectively and the limits of quantitation were 0.924µg/mL and 2.2µg/mL respectively. Accuracy of the method verified by performing recovery using simultaneous equation method and found to be 98 to 99.5%w/w for albendazole and 97.97 to 99.55 %w/w for levamisole hydrochloride. %RSD of repeatability and intermediate precision studies were found to be

Tramadol Hydrochloride is an opioid pain medication which is used to treat moderate to moderately severe pain. Various analytical methods used for the estimation of Tramadol hydrochloride has been reviewed in this paper. These include Ultraviolet spectrophotometry, Visible spectrometry, Spectrofluorimetry, High Performance Liquid Chromatography, Ultra Performance Liquid Chromatography, High Performance Thin Layer Chromatography, Gas Chromatography- mass spectrometry, Cyclic Voltammetry, Liquid Chromatography-Electronspray ionization-mass spectrometry, Gas Chromatography, Liquid Chromatography- mass spectrometry, and Capillary Electrophoresis to determine the amount of Tramadol Hydrochloride in bulk drug, pharmaceutical dosage form and biological fluids. Stability indicating methods for Tramadol Hydrochloride are also described. These analytical methods can be used for qualitative and quantitative estimation of Tramadol Hydrochloride in bulk, formulation and biological fluids.