Renu B. Ghayalkar1* Naushad Zubair

Benz-fused compounds have been employed in the synthesis of various compounds which show very potential pharmacological activities. Carbohydrate is the key element in variety of biological phenomena and its N-linked sugar derivatives also exhibit wide range of medicinal activities. Keeping in this view, when one biological active molecule is linked to another, the resultant molecule generally has increased potency.Hence for the first time, in present work, we have interacted two pharmocophores, hepta-O-benzoyl-β-D-lactosyl isothiocyanate  and substituted 2-hydrazino-1,3-benzothiazoles in acetone medium to yield hepta-O-benzoyl-β-D-lactosyl-3-(2)-hydrazino-1,3-benzothiazolyl thiocarbamides. The identities of these newly synthesised hepta-O-benzoyl-β-D-lactosyl-3-(2)-hydrazino-1,3-benzothiazolyl thiocarbamides have been established on the basis of usual chemical transformations and IR , 1H NMR and Mass spectral studies. The antibacterial and antifungal activities of also reported. Some of these derivatives exhibit significant antimicrobial activity. Key words: Lactosyl isothiocyanate, hydrazino benzothiazoles, lactosyl hydrazino benzothiazolyl thiocarbamides, antimicrobial activity.