Ravi M

The present study investigates the anti-inflammatory activity in ethanolic extract of Canthium Parviflorum using carrageenan induced paw edema in albino rats. The medicinal values of the Canthium Parviflorum have been mentioned ancient literature as useful in disorders of inflammation. Dried leaves of Canthium Parviflorum powdered and extracted with ethanol using soxhlet apparatus. The anti-inflammatory activity was done by carrageenan induced hind paw edema method using plethys mometer. Diclofenac is used as a standard drug. The significant inhibitory activity shown by the leaf extract of Canthium Parviflorum (125, 250, and 375 mg/kg) over a period of 4h in carragenan-induced inflammation was quite similar to that exhibited by the group treated with diclofenac sodium. The highest percentage inhibition activity was found in the dose of 375 mg/kg with the mean percentage inhibition of 23.45% after 4 hours of extract administration.

Garcinia pedunculata is a medicinal plant commonly known as Amlavetasa, belonging to the family Clusiaceae. The fruit of Garcinia pedunculata were used in the diet as a spice. It has been used as folk remedy in different ailments such as chronic catarrh, asthma, cough, bronchitis, cardiotonicand fever. The present study has been carried out to evaluate the anti inflammatory activity of aqueous extract of fruits of Garcinea pedunculata by carrageenan induced paw edema method. Eighteen healthy wistar albino rats were divided into three different groups of six rats each. Group I administered with normal tap water (5ml/kg) served as normal control. Group II administered with Ibuprofen 100mg/kg served as reference standard and group III administered with aqueous extract of fruits of Garcinea pedunculata(400mg/kg). In Acute oral toxicity study there was no mortality in any dose up to 2000mg/kg. The aqueous extract of fruits of Garcinea pedunculata has shown significant anti inflammatory activity by significantly decrease in the paw volume recorded at three different time interval compared with control group (**p< 0.01). It can be concluded that aqueous extract of fruits of Garcinea pedunculatahas potent anti inflammatory activity and there is a need for further scientific investigation to explore its anti inflammatory activity.

Lignocaine Hydrochloride (LH) is a local anesthetic agent used in the treatment of periodontal and various other dental diseases. It undergoes extensive first pass metabolism with a consequent low bioavailability. Keeping this into account the research work was focused to formulate buccal tablets of LH in an effort to achieve prolonged relief from pain. Buccal tablets were prepared by direct compression method using different bio-adhesive polymers such as chitosan with methocel K15, sodium alginate and methocel K4. Ethyl cellulose (EC) was used as an impermeable backing layer. The optimized formula (F9) was evaluated for in vitro drug release (99.51%±0.59) in phosphate buffer for 6 hrs and bio adhesion strength was found to be 22 gr. The amount of drug permeated through the buccal membrane was found to be 85.03 ±0.21.Stability studies of the F9 indicated no significant changes with respect to drug content, in-vitro release and ex-vivo permeation. Key Words: Lignocaine hydrochloride, Buccal drug delivery system, First pass hepatic metabolism, Ex vivo permeation studies.