P. Sirisha

One significant systemic ailment is chronic renal disease. Co-morbid illnesses combined with declining renal function cause patients to take more than one medication. Choosing the right medications is essential to preventing side effects. This study has a prospective observational design in which all patients with chronic kidney disease (CKD) are included in the analysis. Relevant data was acquired through the use of patient data collection forms, which were filled out and examined. In this study, 120 patients who had prescriptions for medications were reviewed prospectively; of these, 76 (63.33%) were men and 44 (36.66%) were women. According to demographic data, men are more likely to develop CKD. According to demographic information, patients between the ages of 41 and 60 were found to be high in 62 middle-aged individuals (51.66%) and low in young adults (7.83%) in the 19–30 age group. Anti-hypertensive medications were the most commonly prescribed class of pharmaceuticals, followed by cardiovascular, hematinic, and anti-diabetic medications. A total of 1.16% of prescriptions were written under their generic names. 10.96% of prescriptions included an injectable products. Antibiotic prescriptions made up 54.16% of all prescriptions. Ninety-three percent of the medications prescribed came from the WHO Essential medicines list. The study shows that the prescription of brand-name medications was frequently noticed using WHO core indicators, which were used to monitor the drug prescribing trend. This study concludes that CKD patients were more likely to be treated with diuretics, antihypertensives, oral hypoglycemic medications, and hematinic agents.

A selective, robust, economic and short method was developed for the simultaneous estimation of the Ertugliflozin (EGZ) and Sitagliptin (SGP) in Tablet dosage form. Chromatogram was run through  X-bridge c18 50 x 2.1 mm, 1.7m. Mobile phase containing Buffer: Acetonitrile taken in the ratio 50:50 was pumped through column at a flow rate of 1 ml/min. Buffer used in this method was 0.01N KH2PO4(3.0PH)buffer. Temperature was maintained at 30°C. Optimized wavelength selected was 240 nm Retention time of EGZ and SGP were found to be 0.883 min and 1.465 min. %RSD of the EGZ and SGP were and found to be 0.3 and 0.8 respectively. %Recovery was obtained as 99.83% and 100.09% for EGZ and SGP respectively. LOD, LOQ values obtained from regression equations of EGZ and SGP were 0.139, 0.421 and 0.18, 0.56 respectively. Regression equation of EGZ is y = 4300x + 253.6, and y = 6814x + 11844 of SGP. Retention times were decreased and that run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries